Top 10 Best diphenhydramine in 2026

Last Updated - 6/17/2026

🏆Best Choice

Amazon Basic Care

Amazon Basic Care Complete Allergy Relief, Diphenhydramine HCl 25 mg, Relieves Symptoms, Antihistamine Tablets, 400 Count

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENT: These allergy relief tablets contain diphenhydramine HCl 25 mg, an antihistamine, which compares to the active ingredient in Benadryl Allergy Tablets
•MULTI-SYMPTOM RELIEF: One dose provides temporary allergy relief of runny nose, sneezing, itching of the nose or throat and itchy, watery eyes; also temporarily relieves runny nose and sneezing due to the common cold
•ANTIHISTAMINE: Each 25 mg allergy pill packs a powerful dose of allergy-fighting medicine; relieves allergy symptoms for 4-6 hours
•SMALL TABLET SIZE: These mini-tabs are easy to swallow, but each one offers big relief; great size for travel
•NIGHTTIME ALLERGY RELIEF: This allergy medicine calms your sneezing so you can rest; gluten free; for adults and children 6 years and over

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$7.99

$8.51

-6%

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Amazon Basic Care

Amazon Basic Care Allergy Relief Diphenhydramine HCl 25 mg, Antihistamine Tablets for Symptoms Due to Hay Fever and Upper Respiratory Allergies, 100 Count

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENT: Amazon Basic Care Allergy Relief tablets contain diphenhydramine HCl 25 mg, an antihistamine, which compares to the active ingredient in Benadryl Allergy Tablets
•MULTI-SYMPTOM RELIEF: One dose provides temporary allergy relief of runny nose, sneezing, itching of the nose or throat and itchy, watery eyes; also temporarily relieves runny nose and sneezing due to the common cold
•ANTIHISTAMINE: Each 25 mg pill packs a powerful dose of allergy-fighting medicine
•MINI-TABS are easy to swallow; these small tablets offer big relief
•NIGHTTIME ALLERGY RELIEF: Amazon Basic Care Complete Allergy Medicine calms your sneezing so you can rest

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$3.99

$4.25

-6%

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Benadryl

Benadryl Ultratabs Allergy Relief Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Relief of Cold & Allergy Symptoms Like Sneezing, Runny Nose, & Itchy Eyes & Throat, 24 ct

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•ALLERGY RELIEF MEDICATION: 24-count package of Benadryl Allergy Tablets for allergy relief help to alleviate symptoms associated with allergies such as sneezing, runny nose, itchy throat or nose, and itchy/watery eyes
•ANTIHISTAMINE TABLETS: This allergy medicine temporarily provides relief of hay fever and other upper respiratory symptoms such as sneezing and runny nose. It also provides relief from common allergens such as tree pollen, dust, mold and pet dander
•COLD SYMPTOM RELIEF: The antihistamine tablets with diphenhydramine hydrochloride feature an effective and powerful formula that works when you need it most. The tablets for multi-symptom relief help tackle both cold and allergy symptoms
•DIPHENHYDRAMINE HCl FORMULA: Benadryl allergy medicine is formulated with 25 mg of diphenhydramine hydrochloride, an antihistamine that works to help provide allergy and upper respiratory relief
•POWERFUL ALLERGY & COLD RELIEF IN JUST 1 PILL: Adults & children 12+, take one to two allergy tablets every four to six hours. Children ages 6-12, take one allergy medicine tablet every four to six hours. Do not give more than six doses in 24 hours

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$5.94

$7.84

-24%

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TIME-CAP LABS, INC.

Timely Allergy Relief Diphenhydramine HCl 25 mg - 650 Caplets - Compared to Benadryl Allergy Ultratab - Antihistamine - Allergy Medication - Runny Nose Relief for Adults - Watery Eyes Treatment

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•Allergy Relief You Can Count On … Timely allergy relief caplets temporarily relieves symptoms due to hay fever or other upper respiratory allergies like runny nose, itchy, watery eyes, sneezing, itchy, nose or throat; temporarily relieves common cold symptoms like runny nose, sneezing.
•Battle Through that Cold … These antihistamine caplets aren’t just great for allergy season. They also help to reduce symptoms of the common cold so that you can get back to doing what you love faster.
•The Same Effect, but Friendlier ... Any allergy relief has to house National Brand equivalency so you can rest assured it's doing the job well. This allergy medicine does, for sure, for less.
•The Superhero of Your First Aid Kit ... Is your first-aid kit bursting with OTC medications & treatments? Stock up and never run out of this allergy medication, which solves more than a runny nose.
•Convenient 25mg Caplets ... These caplets will help you feel like your normal self without the fuss. Can’t stop sneezing? Temporarily relieve it with these antihistamine pills.

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$8.99

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HEALTH LFE

HEALTH LFE Allergy Relief, Medicine Diphenhydramine HCl Caplets, 25 mg | Children and Adults | Relieves Sneezing, Runny Nose, Hay Fever Symptoms, Itchy Eyes and Throat (Large,1000 Count)

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•✅ ACTIVE INGREDIENT: The active ingredient in this product is Diphenhydramine HCl, an antihistamine approved for the treatment of allergies and cold symptoms. Compare HealthLife Allergy Relief to the active ingredient of Benadryl.
•✅ PROVIDES ALLERGY RELIEF: This allergy relief medicine relieves symptoms due to hay fever or other upper respiratory allergies: runny nose, sneezing, itching of the nose or throat and itchy, watery eyes.
•✅ RELIEVES SYMPTOMS OF COMMON COLD: This allergy relief medicine helps to reduce sneezing and itchy noses and throats.

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$9.99

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HealthA2Z

HealthA2Z Sleep Aid 200 Caplets | Diphenhydramine HCl 25mg | Regular Strength Sleeping Pills | Safe & Non-Habit-Forming

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•✅ Uses relief of occasional sleeplessness
•✅ Active ingredient (in each caplet): Diphenhydramine HCl 25 mg
•✅ Does not contain Pain Reliever
•✅ Safe, non-habit-forming: HealthA2Z Sleep Aid can be used for the relief of occasional sleeplessness; this nighttime sleep aid is non-habit forming when used as directed.
•✅ For adults and children: Each caplet of this adult sleep aid contains 25 mg of diphenhydramine hydrochloride as the active ingredient and can be used by adults and children ages 12 years and older.

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$7.45

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HealthA2Z

HealthA2Z® Allergy Relief | Diphenhydramine HCL 25mg | Antihistamine | Relief from Itchy Throat, Sneezing, Runny Noses | Indoor & Outdoors Allergies (200 Caplets (Pack of 1))

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•HealthA2Z Allergy Relief, Diphenhydramine 25mg

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$5.45

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KIRKLAND

Kirkland Signature Allergy Medicine Diphenhydramine HCI 25 mg - 600 Minitabs

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•Relief from sneezing and running nose
•Itching, Watery Eyes;Hay Fever symptoms;
•Itching of Nose or throat.

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$8.99

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HEALTH LFE

HealthPharma Nighttime Sleep-Aid, Diphenhydramine HCL Caplets, 25 mg (Blue), 600 Count

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•✅ Safe, Non-Habit Forming Sleep Aid: Health Pharma sleeping pills are easy to swallow, helps you reach deeper, restful sleep at night. Take 1-2 tablets before bed. Compare to the active ingredient in Simply Sleep.
•✅ Mini Caplets and Not a Pain Reliever: Miniature caplets designed to be easier and safer for those who have trouble swallowing. These sleep aid caplets are purely intended to give you a good night's sleep and contain no unnecessary ingredients.
•✅ EFFECTIVE: Tested and proven effective. Active ingredient Diphenhydramine HCl 25 mg is an antihistamine sleep aid tablets used as allergy relief as well as sleep aid for adults and children ages 12 years and older
•✅ VALUE PACK SAVINGS: Did you know, with Health Pharma Nighttime Sleep aid caplets comes in 600 count value pack can save you significant amount of money with the same active ingredient as Simply Sleep.
•✅ 100% SATISFACTION GUARANTEE: Click Buy Now and get this top rated Nighttime Sleep Aid Caplets formula to help you fall asleep.

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$8.99

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SDA LABORATORIES

SDA LABORATORIES Diphenhydramine HCI Antihistamine 25 mg Capsules for Multi-Symptom Allergy Relief, Sleep Support and Cold Symptoms, 100 Count (1 Bottle)

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•ALLERGY SYMPTOM RELIEF: The capsules provide fast-acting relief from common allergy symptoms like sneezing, runny nose, and itchy eyes. They help manage both indoor and outdoor allergens, making them effective year-round.
•COLD SYMPTOM RELIEF: In addition to treating allergies, this product alleviates cold symptoms such as nasal congestion and throat irritation. It offers relief for those with overlapping allergies and cold issues.
•VERSATILE ANTIHISTAMINE: This product is effective not only for seasonal allergies but also for allergic reactions to pet dander, dust, and insect bites. Its broad range of uses makes it a go-to solution for multiple allergic conditions.
•CONVENIENT CAPSULE FORM: The capsules are easy to swallow, offering precise dosage and fast absorption for quick relief. This form is ideal for those seeking an easy and reliable option for managing allergy symptoms.
•LARGE SUPPLY: The 100-count bottle ensures long-lasting supply, reducing the need for frequent re-purchasing. It's ideal for households or individuals who need consistent allergy management.

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$6.99

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