Top 10 Best dog benadryl in 2026

Last Updated - 6/17/2026

🏆Best Choice

Zesty Paws

Zesty Paws Dog Allergy Relief- Dog Itching Skin Relief- Dog Probiotics for Itchy Skin and Itchy Ears- Dog Allergy Paw Relief- Dog Allergy Chews- Dog Itch Relief - Dog Skin Allergy Relief - Lamb - 90ct

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•ALLERGY RELIEF: Made with premium ingredients to support digestion and immune function, this allergy relief for dogs offeres relief from itchy discomfort and promote overall well-being for your furry friend
•IMMUNE SYSTEM SUPPORT: These allergy chews for dogs and itchy skin feature EpiCor Pets, a whole food yeast fermentate, to help strengthen your dog's immune system for healthy responses
•ITCHY DOG SKIN RELIEF: Contains Colostrum and Astragalus Root, Zesty Paws Allergy Relief Chews provide relief for itchy skin and support normal histamine levels, keeping your dog's skin comfortable
•DOG GUT HEALTH PROBIOTICS: With dog probiotics like Lactobacillus acidophilus, these chews help maintain normal gut flora, enhancing your dog's digestive health and boosting overall wellness
•OMEGA-3 BENEFITS: Provides your dog supplies with Omega-3 fatty acids EPA and DHA, supporting immune health with dog skin allergy relief benefits while providing itch relief for dogs

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$32.97

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Amazon Basic Care

Amazon Basic Care Allergy Relief Diphenhydramine HCl 25 mg, Antihistamine Tablets for Symptoms Due to Hay Fever and Upper Respiratory Allergies, 100 Count

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENT: Amazon Basic Care Allergy Relief tablets contain diphenhydramine HCl 25 mg, an antihistamine, which compares to the active ingredient in Benadryl Allergy Tablets
•MULTI-SYMPTOM RELIEF: One dose provides temporary allergy relief of runny nose, sneezing, itching of the nose or throat and itchy, watery eyes; also temporarily relieves runny nose and sneezing due to the common cold
•ANTIHISTAMINE: Each 25 mg pill packs a powerful dose of allergy-fighting medicine
•MINI-TABS are easy to swallow; these small tablets offer big relief
•NIGHTTIME ALLERGY RELIEF: Amazon Basic Care Complete Allergy Medicine calms your sneezing so you can rest

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Pet MD

Pet MD Hydrocortisone Spray for Dogs, Cats, Horses - Itch Relief Spray & Hot Spot Treatment for Dogs, Irritated Dry Itchy Skin, Allergies, and Dermatitis - Reduces Topical Inflammation - 4 oz

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•1% Hydrocortisone spray: For rapid relief from skin irritations caused by bites and other skin conditions.
•Itch relief for dogs and cats: Our hydrocortisone treatment reduces inflammation, swelling, itching, and redness to help stop the cycle of scratching and biting.
•Non-stinging formula: No fragrance or dyes helps relieve itching without causing further irritation to the skin.
•Hot spot spray for dogs, cats, and horses: Relieves symptoms of hot spots, bites, and skin conditions so your pet can heal quickly.
•Quality you can trust: At Pet MD our products are produced in the USA in facilities with strict inspection and quality controls.

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$16.99

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Benadryl

Benadryl Ultratabs Allergy Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Cold & Allergy Relief of Symptoms Like Sneezing, Runny Nose, Itchy Eyes & Throat, Hay Fever, 100 Count Tablets

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•Multi-Symptom Relief: Small coated Benadryl Ultratabs with 25 mg diphenhydramine HCl provide reliable relief from sneezing, runny nose, itchy throat, and itchy, watery eyes due to hay fever or the common cold
•Portable Allergy Medicine: The convenient 100-count bottle fits in backpacks, purses, or desk drawers so you can keep effective allergy medicine with you. Small, easy-to-swallow oval tablets are ideal for on-the-go allergy control
•Versatile Allergy & Cold Relief: Antihistamine tablets temporarily relieve symptoms from pollen, dust, mold, pet dander, and food-reaction hives; take one tablet every four to six hours, and do not exceed six doses in any 24-hour period as directed
•Active Ingredient & Age Guidance: Each Benadryl Ultratab contains 25 mg diphenhydramine HCl to help ease upper respiratory allergy symptoms; suitable for adults and children ages six and up when used exactly as directed on the product packaging
•Value Pack Supply: 100-count package of allergy relief tablets helps you stay prepared for seasonal peaks and year-round triggers; compact tablets are easy to carry so relief is available at home, work, or travel whenever symptoms strike

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$13.38

$19.74

-32%

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ValuMeds

ValuMeds Allergy Medicine Antihistamine, Diphenhydramine HCl 25 mg | Children and Adults | Relieve Itchy Eyes, Runny Nose, Sneezing (25 mg, 600)

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•Fast-Acting Allergy Relief: Our antihistamine diphenhydramine allergy medicine provides rapid relief from annoying allergy symptoms. Whether it's itchy eyes, runny nose, or sneezing, our powerful formula gets to work quickly, helping you regain control and enjoy your day.
•Quality You Can Trust: Trust in the quality and effectiveness of our antihistamine diphenhydramine allergy medicine. Made with care and precision, it meets rigorous standards to ensure your complete satisfaction. Relieve your allergy symptoms confidently with a trusted brand.
•Restful Sleep and Allergy Relief Combined: Diphenhydramine HCl, a powerful antihistamine comparable to Benadryl, not only provides effective relief from allergy symptoms but also promotes restful sleep, making it an ideal choice for those seeking relief from allergies and a good night's sleep.
•HSA Eligible for Added Convenience: Take advantage of your Health Savings Account (HSA) with our antihistamine diphenhydramine allergy medicine. It's HSA eligible, making it a smart and convenient choice for managing your allergy symptoms and maximizing your healthcare savings.
•Versatile and Allergy-Relieving: Our antihistamine diphenhydramine allergy medicine provides relief for a wide range of allergy symptoms, including sneezing, itching, watery eyes, and more. With its proven effectiveness, it's suitable for adults and children alike, offering reliable relief for the entire family.

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$9.99

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Arm & Hammer

Arm & Hammer for Pets Itch Relief Spray for Dogs - Dog Itch Relief with Baking Soda Chamomile & Peppermint Scent - Professional Dog Skin Care - Anti Itch Spray for Dogs, Itchy Dog Skin Relief 8oz

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•Dog Skin Differs from Humans - Always use dog-specific products like this anti itch spray for dog. Human shampoos can harm a dog’s skin, causing irritation. This dog spray provides proper dog skin care and helps with dog paw itch relief and itchy skin.
•Free of Sodium Lauryl Sulfate & Parabens - This dog spray is perfect for itch relief, free from harsh chemicals. Use it as an anti itch spray for dogs or dog hot spot spray to stop itching for dogs between baths, keeping them fresh and itch-free.
•Professional Quality Dog Itch Relief - This professional dog itching skin relief spray offers quick relief for itchy dog skin. It’s ideal for hotspot relief for dogs and can be used as a dog paw relief spray, leaving a pleasant smell.
•Clean Chamomile & Peppermint Scent - This dog skin care spray not only soothes with chamomile and peppermint but also acts as a dog hot spot spray. It offers much-needed itchy dog skin relief, stopping scratching and itching relief for dogs.

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$4.69

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Benadryl

Benadryl Extra Strength Allergy Relief Medicine, 50 mg Diphenhydramine HCl Antihistamine Tablets for Relief of Allergy Symptoms Due to Hay Fever or Other Upper Respiratory Allergies, 24 ct

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•ALLERGY RELIEF MEDICIATION: 24-count pack of Benadryl Extra Strength Antihistamine Allergy Relief Tablets each containing 50 mg of the antihistamine diphenhydramine hydrochloride for powerful allergy symptom relief
•EXTRA STRENGTH SYMPTOM RELIEF: The allergy medicine provides relief from both indoor & outdoor allergy symptoms such as runny nose, sneezing, itchy, watery eyes, & itchy nose & throat. They also provide symptom relief for hay fever & the common cold
•POWERFUL ANTIHISTAMINE: Formulated with 50 mg diphenhydramine HCl, the extra strength allergy tablets provide relief from hay fever or other upper respiratory allergy symptoms & cold symptoms such as sneezing & runny nose
•FAST & EFFECTIVE: Benadryl Extra Strength Allergy Medicine in small, convenient antihistamine tablets provide effective allergy relief when you need it. Allergy medicine for multi-symptom relief is intended to be used by adults & children ages 12+
•POWERFUL ALLERGY & COLD RELIEF IN JUST 1 PILL: Adults & children over 12 years of age, take one Benadryl Extra Strength Allergy Relief tablet every 4 to 6 hours, or as directed by a doctor, do not take more than 6 times in 24 hours

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$8.17

$12.47

-34%

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Benadryl

Benadryl Ultratabs Allergy Relief Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Relief of Cold & Allergy Symptoms Like Sneezing, Runny Nose, & Itchy Eyes & Throat, 24 ct

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•ALLERGY RELIEF MEDICATION: 24-count package of Benadryl Allergy Tablets for allergy relief help to alleviate symptoms associated with allergies such as sneezing, runny nose, itchy throat or nose, and itchy/watery eyes
•ANTIHISTAMINE TABLETS: This allergy medicine temporarily provides relief of hay fever and other upper respiratory symptoms such as sneezing and runny nose. It also provides relief from common allergens such as tree pollen, dust, mold and pet dander
•COLD SYMPTOM RELIEF: The antihistamine tablets with diphenhydramine hydrochloride feature an effective and powerful formula that works when you need it most. The tablets for multi-symptom relief help tackle both cold and allergy symptoms
•DIPHENHYDRAMINE HCl FORMULA: Benadryl allergy medicine is formulated with 25 mg of diphenhydramine hydrochloride, an antihistamine that works to help provide allergy and upper respiratory relief
•POWERFUL ALLERGY & COLD RELIEF IN JUST 1 PILL: Adults & children 12+, take one to two allergy tablets every four to six hours. Children ages 6-12, take one allergy medicine tablet every four to six hours. Do not give more than six doses in 24 hours

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$5.84

$7.84

-26%

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PetArmor

PetArmor Antihistamine Allergy Relief for Dogs, Easy-to-Use Allergy Medicine for Dogs, Anti-Itch Medicine Provides Relief from Insect Bites, and Stings, 100 Tablets

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•SAME INGREDIENTS: These PETARMOR tablets contain the same active ingredient as BENADRYL Allergy ULTRATABS.
•AFFORDABLE AT-HOME TREATMENT: Skip the trip to the vet with PETARMOR's Antihistamine tablets for dogs. The affordable at-home treatment.
•PROVIDES TEMPORARY RELIEF: This skin health supplement for dogs treats sensitive itchy skin, insect bites, and stings.
•EASY TO USE: These antihistamine tablets are simple and easy to use.
•COST-SAVINGS: 100 PETARMOR tablets in each container, 25 mg each.

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$5.49

$5.99

-8%

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ProSense

Pro-Sense Itch And Allergy Solutions, For Dogs, Antihistamine, 100 Count

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•Fast relief for allergy symptoms
•Helps reduce itching caused by allergies and other minor skin irritations
•Soothes itchy, watery eyes
•Use only as directed for pets
•Packaging may vary

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$6.65

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