Top 10 Best heartburn medicine in 2026

Last Updated - 6/13/2026

🏆Best Choice

Amazon Basic Care

Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENT: The active ingredient in these delayed release tablets is omeprazole 20 mg, which works as an acid reducer to treat frequent heartburn. Compare to Prilosec OTC
•TREATS FREQUENT HEARTBURN: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg treat frequent heartburn that occurs 2 or more times a week
•ACID REDUCER: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is a Proton Pump Inhibitor (PPI) that deactivates pumps in the stomach lining to inhibit acid production at the source.
•14-DAY COURSE OF HEARTBURN TREATMENT: Taken once every 24 hours for 14 days, Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is not intended for immediate relief of heartburn and may take 1 to 4 days for full effect.
•HEARTBURN TIPS: Do not eat late at night or just before bedtime. Certain foods or drinks are more likely to cause heartburn, such as rich, spicy, fatty and fried foods, chocolate, caffeine, alcohol and even some fruits and vegetables.
•Product may be manufactured in India or Israel

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$9.53

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Amazon Basic Care

Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 28 Count (Packaging may vary)

9.6

ChoiceComparer.com Score

9.6

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENT: The active ingredient in these delayed release tablets is omeprazole 20 mg, which works as an acid reducer to treat frequent heartburn. Compare to Prilosec OTC.
•TREATS FREQUENT HEARTBURN: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg treat frequent heartburn that occurs 2 or more times a week.
•ACID REDUCER: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is a Proton Pump Inhibitor (PPI) that deactivates pumps in the stomach lining to inhibit acid production at the source.
•14-DAY COURSE OF HEARTBURN TREATMENT: Taken once every 24 hours for 14 days, Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is not intended for immediate relief of heartburn and may take 1 to 4 days for full effect.
•HEARTBURN TIPS: Do not eat late at night or just before bedtime. Certain foods or drinks are more likely to cause heartburn, such as rich, spicy, fatty and fried foods, chocolate, caffeine, alcohol and even some fruits and vegetables.

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$6.29

$7.77

-19%

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Amazon Basic Care

Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENT: This product contains 20 mg of famotidine, an acid reducer for heartburn relief, which compares to the active ingredient in Maximum Strength Pepcid AC.
•RELIEVES HEARTBURN: Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg help to relieve heartburn due to acid indigestion and sour stomach. PREVENTS
•HEARTBURN: Taken 10 to 60 minutes ahead of time, Amazon Basic Care Famotidine Tablets 20 mg prevents heartburn due to acid indigestion brought on by eating and drinking certain foods and beverages. JUST
•ONE TABLET prevents and relieves heartburn due to acid indigestion brought on by eating and drinking certain foods and beverages. This heartburn medicine lasts up to 12 hours. Use for adults & children 12 years and over. This product is gluten free.
•HEARTBURN MEDICINE: The active ingredient in Amazon Basic Care Famotidine Tablets 20 mg is an H2-blocker, which works as an acid reducer to help relieve heartburn. Lasts up to 12 hours. Use for adults and children 12 years and over.
•"Product may be manufactured in India or U.S."

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$10.07

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Pepcid

Pepcid AC Maximum Strength Heartburn Relief Tablets, OTC Medicine Prevents & Relieves Heartburn & Acid Reflux Due to Acid Indigestion, 20mg Famotidine Acid Reducer, Fast-Acting, 25 ct

9.3

ChoiceComparer.com Score

9.3

/ 10

Excellent

Main highlights

•25-count of Maximum Strength Pepcid AC All-Day Heartburn Relief Tablets with famotidine, for the prevention and relief of heartburn and acid reflux due to acid indigestion and sour stomach
•Just 1 tablet of the extra strength heartburn medicine controls acid all day or all night (based on 9-hour acid control studies during the day and 12-hour acid control studies during the night. Acid control does not imply symptom relief)
•Each over-the-counter heartburn relief tablet is specially formulated with 20 milligrams of famotidine, a known acid reducer and controller for maximum strength aid in the relief and prevention of acid indigestion
•This maximum strength tablet for acid reflux can be taken as early as 60 minutes prior to eating, or in as little as 10 minutes before consuming food and beverages that contribute to heartburn
•Keep a package of the acid indigestion relief tablets at home and in the office to relieve heartburn whenever it strikes. Adults & children 12+, swallow one tablet with a glass of water; do not chew. Do not take more than two tablets in 24 hours

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$10.59

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Amazon Basic Care

Amazon Basic Care Heartburn & Gas SuperChews Chewable Tablets, Mixed Berry, 82 Count (Previously SoundHealth)

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•Chewy Not Chalky: Fast-acting relief for heartburn, gas, sour stomach, and bloating from 750 mg of calcium carbonate and 80 mg of Simethicone in an enjoyable product form
•Full of Flavor: Delicious mixed berry flavors are easily accessible in an easy-to-open flip cap bottle. Adults and children 12 years and up can take 1-2 chewable tablets every 2-4 hours as needed.
•Same Benefits, Lower Cost: Amazon Basic Care Antacid Fruit Chews are formulated to include the same active ingredients and provide the same relief as the name brand, but at a lower price to consumers
•This product was previously a SoundHealth product. Now it’s a part of the Amazon Basic Care Brand, the product is the exact same formulations, size, and quality.
•An Amazon Brand

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$9.09

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HealthA2Z

HealthA2Z® Acid Reducer | Famotidine 20mg | Maximum Strength | Relief from Heart Burn Due to Acid Indigestion (100 Tablets (Pack of 1))

9.0

ChoiceComparer.com Score

9.0

/ 10

Great

Main highlights

•Relieve Heartburn: Heartburn happens when stomach acid backs up into your esophagus, causing a painful, burning sensation in your chest and throat.
•Relieve stomach acid and indigestion: Get the relief you need with HealthA2Z Famotidine Tablets, 20 mg. This acid reducer prevents and relieves heartburn due to acid indigestion and sour stomach.
•Works in 6-12 hours: HealthA2Z famotidine 20mg, Acid reducers provide relief for 6-12 hours by decreasing the amount of acid in the stomach.
•Directions: Take with a glass of water. Adults and children 12 years of age and over: 1 tablet in a single daily dose with a glass of water. Do not chew. To Prevent symptoms, swallow 1 tablet with a glass of water at any time from 15 to 60 minutes before eating food & beverages that that cause heartburn. do not use more than 2 tablets in 24 hours. Children under 12 years of age: ask a doctor.

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$6.95

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TIME-CAP LABS, INC.

Timely Esomeprazole Magnesium 20mg Antacid Pills - Stomach Acid Reducer, Frequent Heartburn Relief & Acid Reflux Medicine - 24 Hour Esomeprazole Delayed Release Capsules - 42 Count

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•ACTIVE INGREDIENT: Don’t let heartburn ruin your day or interrupt your night. With 20mg of esomeprazole magnesium per capsule, Timely acid reducer pills and heartburn relief medicine keeps frequent heart burns and acid reflux in check around the clock.
•ACID REDUCER: Esomeprazole magnesium heartburn pills deactivate acid-producing pumps in the stomach lining to treat frequent heartburn caused by acid reflux all day and night. This acid controller formula inhibits acid production and heart burn at the source and is designed for those who suffer from chronic heartburn symptoms for an effective relief.
•SUPER EFFECTIVE: Thanks to the delayed-release capsules, this antacids for acid reflux gets to where it's needed while still having maximum potency. No more taking antacid tablets multiple times. One capsule per day of Timely esomeprazole magnesium is all it takes to escape the woes of acid reflux. Please Note: It may take 1-4 days for the acid reducer to work fully.
•GREAT VALUE: Don't fall into the branding trap. Timely generic esomeprazole heartburn medicine is a trusted and effective alternative acid reflux relief heart burn medicine, offering the same high-quality treatment at 3x more affordable price point than national brands. Be savvy. Shop smart. Save big.
•24 HOUR RELIEF: Just one easy to swallow capsule daily helps provide 24-hour relief. Our heart burn or acid reflux medicine help you get through your day and sleep restfully at night without heartburn symptoms. Enjoy foods and beverages that could cause frequent heartburn. Ideal for those who want a simple, no-hassle way to manage their indigestion and heartburn relief.

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$7.90

$8.99

-12%

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Ohm

Ohm Esomeprazole Magnesium Delayed Release Capsules 20mg - Frequent Heartburn & Acid Reflux Relief, 24 Hour Chest & Stomach Acid Reducer, Antacid Pills, Digestive Support (42 Capsules)

8.7

ChoiceComparer.com Score

8.7

/ 10

Good

Main highlights

•Effective Acid Reducer: Experience powerful relief with our Esomeprazole Magnesium USP 20mg capsules, designed as an effective acid reducer to combat acid reflux and prevent frequent heartburn, offering 24-hour relief from discomfort.
•24-Hour Relief: Our acid reflux medicine provides extended 24-hour relief, ensuring you remain free from heartburn and acid reflux discomfort throughout the day, thanks to its delayed release formula that acts as a reliable anti acid.
•Trusted Formula: This product is formulated to provide the same active ingredient of Nexium 24HR, offering comparable effectiveness and trusted relief for your needs.
•Comprehensive Heartburn Solution: Designed for those experiencing frequent heartburn, our esomeprazole magnesium delayed release capsules serve as effective heartburn pills, acting as a potent stomach acid reducer and providing consistent gerd medicine support.
•Enhanced Digestive Support: Our heart burn pills offer more than just relief from acid upset and stomach pain. They serve as reliable heart burn medicines, providing enhanced digestive support and ensuring lasting relief from indigestion and reflux.

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$12.99

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Prilosec

Prilosec OTC, Omeprazole Delayed Release 20mg, Acid Reducer, Treats Frequent Heartburn for 24 Hour Relief, All Day, All Night*, Heartburn Medicine, 20mg, 14 Tablets

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•BLOCKS HEARTBURN BEFORE IT STARTS. Starts working on Day 1* to prevent excess acid production, tackling the root cause of your heartburn instead of just masking the symptoms
•SIMPLE, EFFECTIVE HEARTBURN RELIEF. Just 1 pill each morning is all it takes for 24 hour relief. No more juggling multiple doses or treatments
•ZERO HEARTBURN* FOR 24 HOURS WITH 1 PILL A DAY. Each pill contains active ingredient omeprazole 20mg, an acid reducer that provides long-lasting, heartburn relief*
•ALL-DAY & ALL-NIGHT HEARTBURN PROTECTION so you can live life heartburn-free*, unlike Antacids which only last 1 - 3 hours**. **Use all heartburn medications as directed.
•#1 DOCTOR & GASTROENTEROLOGIST RECOMMENDED frequent heartburn medicine for over 15 years. IQVIA ProVoice Survey, 2005 - 2022.

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$6.97

$9.98

-30%

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