Top 10 Best antidiarrheal medications in 2026

Main highlights

• •18-count package of Imodium Multi-Symptom Diarrhea Relief Caplets with loperamide HCl & simethicone for effective relief of diarrhea and upset stomach symptoms
• •Imodium Multi-Symptom Relief is the only branded product that provides diarrhea relief while also helping to alleviate abdominal symptoms such as gas & bloating by working with your body to slow down your digestive system & restore its natural rhythm & balance
• •Each caplet of anti-diarrhea medicine contains 2 mg of loperamide hydrochloride for acute diarrhea relief & 125 mg of simethicone to help treat symptoms associated with gas-related abdominal discomfort including bloating, pressure, gas & cramps
• •No other branded anti-diarrheal medicine combines the two powerful ingredients of loperamide HCl & simethicone for multi-symptom relief. Imodium Multi-Symptom Relief Caplets are HSA/FSA eligible. Check with your provider for complete coverage details
• •From #1 doctor-recommended OTC brand of anti-diarrheals, these medicine caplets are suitable for use by adults & children ages 6 years & older. Pack this travel essential in your carry-on, purse, or backpack for diarrhea relief on-the-go

Main highlights

• •MULTI-SYMPTOM RELIEF: Pepto Bismol Liquicaps provide fast and effective relief from nausea, heartburn, indigestion, upset stomach, and diarrhea
• •#1 PHARMACIST RECOMMENDED Brand for Upset Stomachs
• •CALMS AND SOOTHES: Pepto Bismol’s coating action calms your stomach and soothes your digestive tract to provide effective relief from nausea, heartburn, indigestion, upset stomach, and diarrhea
• •CONVENIENT FORM: Pepto Bismol Liquicaps are a convenient way to get on-the-go relief from your upset stomach symptoms
• •HIGH QUALITY: As a part of the P&G family, Pepto Bismol has high quality standards for all our products

Main highlights

• •Calm Upset Stomach: For diarrhea, stomach upset, nausea, indigestion, gas & more you can trust the calm, soothing relief that starts when you take your first dose of Kaopectate Multi-Symptom Relief.
• •Easy, On-The-Go Relief: Diarrhea & upset stomach can strike anywhere, so get the Kaopectate that goes everywhere! Our convenient caplets offer quick, multi-symptom relief that you can take anywhere.
• •Seven Symptom Relief: Kaopectate liquids & caplets offer quick, temporary relief from seven types of stomach discomfort, including traveler's diarrhea, heartburn, nausea, gas, & indigestion.
• •Trusted Formula: Kaopectate liquid & caplet products are formulated with Bismuth subsalicylate, a trusted antacid ingredient proven to help relieve temporary stomach and GI discomfort.
• •Targets Source: Kaopectate offers medical solutions to relieve symptoms of nausea, gas, indigestion, diarrhea, upset stomach, & heartburn. Try our liquid & caplet medicines for relieving GI discomfort.

Main highlights

• •ACTIVE INGREDIENTS: This product contains loperamide hydrochloride 2 mg, anti-diarrheal, and simethicone 125 mg, anti-gas, which compares to the active ingredients of Imodium Multi-Symptom Relief.
• •MULTI-SYMPTOM RELIEF: This anti-diarrheal and anti-gas medicine relieves symptoms of diarrhea plus bloating, pressure and cramps, commonly referred to as gas.
• •WHAT IS DIARRHEA: Diarrhea is a loose and watery bowel movement and very common as many people may have it once or twice a year. Usually not serious, it will typically last two or three days and is normally treated with an over-the-counter medication.
• •DIARRHEA FACT: Properly washing hands can help eliminate the spread of infection that causes a serious type of diarrhea.
• •HELP PREVENT DEHYDRATION: Drink plenty of clear fluids to help prevent dehydration caused by diarrhea.

Main highlights

• •8-fluid ounce bottle of Imodium A-D Liquid Diarrhea Medicine with loperamide HCl helps control and treat diarrhea symptoms for fast, effective relief
• •The proven formula of this anti-diarrhea liquid medicine helps control symptoms of diarrhea and is designed to work with your body to slow down your gut and restore its natural rhythm and balance
• •The anti-diarrhea oral solution contains 1 mg of loperamide hydrochloride in every 7.5 mL to help control symptoms of diarrhea due to acute, Traveler's diarrhea. Pack this travel essential in your purse or backpack for relief on-the-go
• •The adult anti-diarrheal medicine is available in an easy-to-take liquid formula with a classic mint flavor. Imodium A-D Liquid Anti-Diarrheal Medication is HSA/FSA eligible. Check with your provider for complete coverage details
• •From the #1 doctor-recommended OTC anti-diarrheal brand for symptom relief and control, this diarrhea liquid works fast to relieve your diarrhea symptoms

Main highlights

• •STARTS WORKING IMMEDIATELY: Kaopectate Strawberry Soft Chews start working immediately to provide effective diarrhea medication for adults, utilizing bismuth subsalicylate to target symptoms quickly.
• •QUICKLY RELIEVES URGENCY, GAS, AND CRAMPING: This anti-diarrhea medicine offers fast stomach relief, addressing urgency, gas, and cramping to help you feel better sooner.
• •WORKS ON VARIOUS DIARRHEA CAUSES: Whether caused by bacteria, viruses, or other factors, Kaopectate's bismuth formula, including bismuth crystals, provides comprehensive diarrhea medicine for upset stomach relief for adults.
• •DELICIOUS FLAVOR AND CONVENIENT TO USE: Enjoy the pleasant strawberry flavor of these soft chews, making them a great-tasting and easy-to-take solution for stomach soothe and settle.
• •TRUSTED ANTI-DIARRHEA SOLUTION: Comparable to Imodium AD and Banatrol Plus with probiotic anti-diarrhea benefits, Kaopectate for diarrhea is a trusted choice for the best diarrhea medicine and overall digestive health.

Main highlights

• •Effective Relief: Multi-Symptom Relief Tablets offer powerful relief from diarrhea and gas discomfort, helping you regain comfort and confidence in your daily activities. COMPARE TO National Brand Multi-Symptom active ingredient
• •Advanced Formulation: Formulated with loperamide hydrochloride 2 mg to control diarrhea and simethicone 125 mg, to alleviate gas and bloating. Our tablets are carefully crafted to target multiple symptoms, for comprehensive digestive relief
• •Fast-Acting Formula: Provides rapid relief from digestive discomfort, including diarrhea, gas, bloating, abdominal pressure, and cramps, helping you feel better quickly and resume your daily activities without interruption.

Main highlights

• •12-count package of Imodium A-D Softgels with loperamide HCl to help control and treat diarrhea symptoms for effective relief
• •The proven formula of this anti-diarrheal medicine works with your body to slow down your digestive system & helps restore its natural rhythm and balance. Pack this travel essential in your carry-on, purse, or backpack for traveler's diarrhea relief on-the-go
• •Suitable for adults and children ages 12 years and up, each anti-diarrhea medicine softgel contains 2 milligrams of loperamide hydrochloride to help control symptoms of diarrhea due to acute, Traveler's diarrhea
• •From the #1 doctor-recommended OTC anti-diarrheal brand for symptom relief and control, this diarrhea medication works faster than the prescription anti-diarrheal medication Lomotil, containing diphenoxylate and atropine
• •Available in convenient tear-away packaging, they are ideal for use both at home and on-the-go to effectively control symptoms. Imodium A-D Softgels are HSA/FSA eligible. Check with your provider for complete coverage details

Main highlights