Top 10 Best cat flea and tick in 2026

Last Updated - 6/8/2026

🏆Best Choice

Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 4-Month Supply

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
•Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
•Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
•Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
•Fragrance-free formula, waterproof after 24 hours of application

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$51.98

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Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 2-Month Supply

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
•Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
•Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
•Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
•Fragrance-free formula, waterproof after 24 hours of application

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Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
•Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
•Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
•Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
•Fragrance-free formula, waterproof after 24 hours of application

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$68.98

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Amazon Basics

Amazon Basics Flea and Tick Topical Treatment for Cats (Over 1.5 Pounds), 6 Count (Previously Solimo)

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•Same product, new look―This product is identical in manufacturing and formulation as the Solimo brand
•One 6 dose pack of Amazon Basics Flea & Tick Treatment for Cats (over 1.5 lbs)
•Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
•Active ingredients (list ingredients) prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
•One application provides up to 30 days of protection
•Waterproof: 24 hours after application your pet’s treatment is protected against rain and water activities
•Packaging received may vary: you may receive product in Solimo or Amazon Basics Packaging.
•Amazon Basics Flea and Tick Topical does not expire
•Satisfaction Guarantee: We’re proud of our products. If you aren’t satisfied, we’ll refund you for any reason within a year of purchase. 1-877-485-0385

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$21.59

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Advantage

Advantage Topical Cat Flea Treatment and Prevention for Small Cats 2-9 lbs. | Apply Flea Drops Monthly | 2 Treatments

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•An excellent value from Advantage, a leading brand that has been trusted to protect cats from fleas for more than 20 years
•Advantage for Small Cats provides flea treatment and prevention for small cats 2-9 lbs., at least 8 weeks of age
•Easy-to-apply monthly topical treatment – no hard-to-swallow pills
•Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
•Fragrance-free and waterproof formula

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$14.98

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TevraPet

TevraPet FirstAct Plus Flea and Tick Prevention for Cats Over 1.5lbs, 6 Monthly Doses, Topical Drops

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•COMPARE TO FRONTLINE PLUS FOR CATS - Contains fipronil and (S)-Methoprene, the same fast acting, vet quality active ingredients as the leading brand
•Breaks flea life cycle - FirstAct Plus topical stops infestations and prevents new ones. Repels and kills fleas and ticks on contact, and kills flea eggs and larvae, chewing lice, and all stages of ticks including those that may transmit Lyme disease
•Powerful and affordable flea protection - your cat is protected Tip to Tail for 30 days with each easy to apply application
•6 month supply - includes 6 topical doses of flea and tick prevention; apply these flea drops to the base of your cat's neck once every 30 days
•RESULTS GUARANTEED: Made in Germany in a certified eu-gmp facility, tested to meet rigorous standards of quality and consistency

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$34.97

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Hartz

Hartz UltraGuard Topical Flea & Tick Prevention for Cats and Kittens - 3 Monthly Treatments

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•Topical drop formula kills fleas and deer ticks
•Includes 3 monthly treatments in easy to apply, single dose tubes
•Repels mosquitoes for 18 days
•For use on cats and kittens 12 weeks and older weighing 5 pounds and over

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$5.92

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Advantage

Advantage Topical Cat Flea Treatment and Prevention for Large Cats Over 9 lbs. | Apply Flea Drops Monthly | 2 Treatments

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•An excellent value from Advantage, a leading brand that has been trusted to protect cats from fleas for more than 20 years
•Advantage for Large Cats provides flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
•Easy-to-apply monthly topical treatment – no hard-to-swallow pills
•Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
•Fragrance-free and waterproof formula

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$14.98

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PetArmor

PetArmor for Cats, Flea & Tick Treatment for Cats (Over 1.5 Pounds), Includes 3 Month Supply of Topical Flea Treatments

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•CAT FLEA AND TICK CONTROL: SENTRY Fiproguard topical flea and tick prevention for cats kills fleas, ticks and chewing lice for up to 30 days.
•VET QUALITY FORMULA: SENTRY Fiproguard is a vet-quality formula flea treatment that contains the active ingredient fipronil.
•FOR KITTENS AND CATS: PetArmor topical flea treatment for cats and kittens 8 weeks and older for up to 30 days after application and helps prevents infestations of adult fleas.
•FLEA AND TICK PREVENTION: PetArmor for cats helps you protect your furry family member from the diseases fleas and ticks carry, including deer ticks that may transmit Lyme disease.
•INCLUDES: Three (3) 0.017 fl. oz. waterproof topical applications for cat flea and tick control. For best results, apply flea and tick treatment for cats directly to dry skin on your cats back, between the shoulder blades, on a monthly basis.

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$11.58

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Fiproguard

Sentry Fiproguard for Cats, Flea and Tick Prevention for Cats, 1.5 lbs and Over, 6 Month Supply

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•CAT FLEA AND TICK CONTROL: SENTRY Fiproguard topical flea and tick prevention for cats kills fleas, ticks and chewing lice for up to 30 days.
•VET QUALITY FORMULA: SENTRY Fiproguard is a vet-quality formula flea treatment that contains the active ingredient fipronil.
•FOR KITTENS AND CATS: Flea and tick control can be used on cats and kittens 8 weeks and older, and 1.5 pounds and older.
•TICK PREVENTION: Fiproguard for dogs also kills brown dog ticks, American dog ticks, lone star ticks and deer ticks
•INCLUDES: Six (6) 0.017 fl. oz. applicators, a six month supply of waterproof topical applications for cat flea and tick control. For best results, apply flea & tick treatment for cats directly to dry skin on your cat's back-between the shoulder blades-on a monthly basis.

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$25.09

$27.22

-8%

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With our cutting-edge technology, we examine thousands of products and retailers, assessing reviews, ratings, trends, and sales rankings to identify what matters most to users like you.

Our team evaluates this data alongside genuine user feedback, merging AI analysis with human insights to provide you with real-time, highly-rated recommendations that empower your decision-making with clarity and confidence.