Top 10 Best enzyme cleaner in 2026

Last Updated - 6/8/2026

🏆Best Choice

Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
•Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
•Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
•Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
•Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it rightx

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$23.92

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Bioda

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•THE POWER OF ONE: This versatile product is the only probiotic cleaner you need, providing powerful cleaning performance in a wide variety of applications. Multipurpose use: Maintain clean drain lines and septic tanks to prevent clogs and potential buildup. Clean and deodorize trash bins, stains and odors on floors, carpets, bathroom surfaces, kitchen surfaces, and more.
•ACTIVE UP TO 21 DAYS: Our specialized probiotics continue to clean soils in cracks, grout and tough to reach places. Simply spray & let the probiotics do the dirty work!
•NATURALLY, SUPERIOR RESULTS: A special blend of enzyme-producing probiotics break down complex proteins, fats, oils, greases, and other organic waste. The enzymes digest the soils until they have been eliminated, providing a long-lasting, continuous clean without leaving a residue or harmful by-products behind.
•ELIMINATE ODOR: Provide total odor control by eliminating the actual source of even the most pungent organic malodors naturally, including rotting food, urine, feces, vomit, and trash. Plus, the fresh lemon and sage fragrance leaves behind a light, pleasant scent that rejuvenates the air of any environment.
•MADE IN THE USA - 1 Gallon Bottle

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$25.99

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Resolve

Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•DESTOYS URINE ODORS THE FIRST TIME: Urine elimination technology neutralizes and removes odors on contact for immediate freshness
•REMOVES PET STAINS AND MORE: Effectively tackles pet stains, food stains, and other tough messes
•HELPS PREVENT REMARKING: Discourages pets from returning to make a mess in the same spot
•SUITABLE FOR USE AROUND PETS: Suitable for use around pets when used as directed
•MULTIPURPOSE USE: Effective on most carpets, fabrics and hard surfaces for versatile cleaning
•FROM THE #1 PET MESS CLEANING BRAND: Trusted by pet owners for superior cleaning performance.

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$6.64

$9.98

-33%

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Nature's Miracle

Nature’s Miracle Urine Destroyer Plus Cat, 32 Ounces, Enzymatic Formula, Ready-to-Use

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•FOR CAT URINE MESSES: Begins to break down and remove stains immediately on contact.
•POWERFUL FORMULA: Just soak the affected area, allow to work for 15 minutes, then blot up stain with a clean cloth.
•ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
•TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works!
•SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets and in your home.

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$12.72

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Nature's Miracle

Nature's Miracle Urine Destroyer Plus for Cats, Enzymatic Formula for Severe Cat Urine Stains, 1 Gal

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•FOR CAT URINE MESSES: Begins to break down and remove stains immediately on contact.
•GREAT FOR REFILLS: The 128-ounce bottle is easy to pour and great for refilling smaller bottles.
•ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
•TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works!
•SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets and in your home.

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$31.69

$37.49

-15%

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Zep

Zep Urine Remover 128 Ounces Targets and Eliminates Urine Odors and Stains

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•Zep Urine Remover 128 Ounces Targets and Eliminates Urine Odors and Stains
•Professional strength urine remover for carpets, mattresses, upholstery, floors and more
•Permanent odor neutralizer with no masking fragrances
•Removes pet, cat and dog urine odors permanently
•Use on urine stains and odors on carpets, mattresses, upholstery, floors, concrete, wood, RVs, boats and more

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$14.18

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Nature's Miracle

Nature's Miracle Advanced Cat Stain and Odor Eliminator Spray, Severe Mess Enzymatic Formula, 32 fl oz

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•FOR SEVERE CAT MESSES: Powerful enzymatic formula works to eliminate tough stains and odors from cat urine, diarrhea, vomit and other bio-based accidents.
•LIGHT FRESH SCENT: Cat odor control formula gets your home smelling clean again.
•ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
•DISCOURAGES RESOILING: Removes the odor from even the toughest cat messes.
•TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works!

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$13.57

$15.99

-15%

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Nature's Miracle

Nature's Miracle Stain and Odor Remover, Spot Stain and Pet Odor Eliminator, Enzymatic Formula, 32 Ounce Spray

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•SPOT STAIN & ODOR REMOVER: Begins to break down and remove cat stains immediately on contact.
•LIGHT CITRUS SCENT: Cat odor control formula gets your home smelling clean again.
•ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
•TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works.
•SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets.

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$10.77

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Nature's Miracle

Nature's Miracle Urine Destroyer Plus for Cats, Enzymatic Formula for Severe Cat Urine Stains, 17.5 oz

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•FOR CAT URINE MESSES: Powerful enzymatic foam is tough on strong cat urine and the yellow, sticky residue.
•FOAMING AEROSOL: Spray until foam covers the mess to penetrate carpet fibers.
•ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
•TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works!
•SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets and in your home.

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$8.87

$10.49

-15%

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Theochem

Theochem I Love My Pet Bio-Enzyme Stain and Odor Eliminator for Home, Enzyme Cleaner, Pet Carpet Cleaner Spray, Pee, Carpet Stain Remover Spray, 32 oz Fresh Scent

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•BIO ENZYMATIC ACTION: Professional strength enzyme cleaner breaks down cat urine, dog poop, blood, and vomit, removes tough stains and odors
•DEEP ODOR AND STAIN REMOVER: Penetrates fibers and padding; tackles set in smells and discoloration; helps reduce remarking on treated areas
•MULTI SURFACE SAFE: For carpet, rugs, upholstery, couches, mattresses, sealed hardwood, tile, grout, concrete, trash cans, and car interiors
•SAFE & NON-TOXIC: Made with natural, eco-friendly and biodegradable ingredients safe for pets, children, carpets, upholstery, and hard surfaces
•OVERNIGHT SENSATION: For set-in and older stains, naturally breaks down stains and odors while you sleep, leaving your home fresh and clean
•FRESH SCENT: Pleasant scent leaves your home smelling clean and refreshing, neutralizing pet odors without overpowering fragrances
•EASY TO USE: Simply spray, wait, and blot or wipe away; no scrubbing required for fast and effective results; can also be used in carpet cleaning machines
•HELPS PREVENT RE-SOILING: By completely eliminating the source of the odor, our cleaner removes the markers that attract pets back to the same spot, aiding in house-training and preventing future accidents
•FIELD-TESTED FOR REAL RESULTS: Tough on stains yet safe for everyday use, our cleaners are battle-tested in real homes and businesses to deliver fast, reliable results
•COMMITTED TO A CLEANER WORLD: As industry leaders, we're dedicated to safe, innovative formulas that make life simple and superior for everyday use, tailored to protect what matters most

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$22.49

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