Top 10 Best dog pee enzyme cleaner in 2026

Last Updated - 6/20/2026

🏆Best Choice

Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
•Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
•Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
•Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
•Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it rightx

View offer on:

$23.92

Check Price

Resolve

Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•DESTOYS URINE ODORS THE FIRST TIME: Urine elimination technology neutralizes and removes odors on contact for immediate freshness
•REMOVES PET STAINS AND MORE: Effectively tackles pet stains, food stains, and other tough messes
•HELPS PREVENT REMARKING: Discourages pets from returning to make a mess in the same spot
•SUITABLE FOR USE AROUND PETS: Suitable for use around pets when used as directed
•MULTIPURPOSE USE: Effective on most carpets, fabrics and hard surfaces for versatile cleaning
•FROM THE #1 PET MESS CLEANING BRAND: Trusted by pet owners for superior cleaning performance.

View offer on:

$6.64

$9.98

-33%

Check Price

ANGRY ORANGE

ANGRY ORANGE Pet Odor Eliminator for Dog and Cat Urine, Carpet Stains, and Strong Smells – Citrus Cleaner with Natural Orange Oil – 24 oz

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•DESTROYS TOUGH PET ODORS – Tackles strong smells from dog and cat urine, feces, vomit, and more. Works fast to eliminate lingering odors at the source.
•CLEANS STAINS ON FLOORS & MORE – Designed for use on hard and sealed surfaces where pet messes happen most. Works fast to eliminate lingering odors at the source.
•SCENT POWERED BY NATURAL ORANGE OIL – Has the power of real orange oil, leaving a pleasant citrus scent behind without harsh smells.
•SAFE FOR HOMES WITH PETS WHEN USED AS DIRECTED – No added parabens, sulfates, or phthalates. No chemical stink. Powerful cleaning without the harsh stink.
•MADE IN THE USA – Proudly formulated and manufactured in the USA for pet owners who care about quality and safety.

View offer on:

$17.96

$19.97

-10%

Check Price

Nature's Miracle

Nature’s Miracle Urine Destroyer Plus Dog, 32 Ounces, Enzymatic Formula, Ready-to-Use

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•FOR DOG URINE MESSES: Begins to break down and remove stains immediately on contact.
•POWERFUL FORMULA: Just soak the affected area, allow to work for 15 minutes, then blot up stain with a clean cloth.
•ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
•TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works!
•SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets and in your home.

View offer on:

$12.99

Check Price

Nature's Miracle

Nature’s Miracle Advanced Stain and Odor Eliminator Dog Spray, Fresh Scent, Severe Mess Enzymatic Formula For Tough Pet Messes, 32 Ounces

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•FOR SEVERE DOG MESSES: Powerful enzymatic formula works to eliminate tough stains and odors from dog urine, diarrhea, vomit and other bio-based accidents.
•LIGHT FRESH SCENT: Dog odor control formula gets your home smelling clean again.
•ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
•DISCOURAGES RESOILING: Removes the odor from even the toughest dog messes.
•TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works!

View offer on:

$13.57

$15.99

-15%

Check Price

Nature's Miracle

Nature’s Miracle Stain and Odor Remover Dog, 32 Ounces, Everyday Mess Enzymatic Odor Control Formula

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•SPOT STAIN & ODOR REMOVER: Begins to break down and remove stains immediately on contact.
•LIGHT CITRUS SCENT: Dog odor control formula gets your home smelling clean again.
•ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
•TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works!
•SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets.

View offer on:

$10.77

$12.99

-17%

Check Price

Nature's Miracle

Nature's Miracle Stain and Odor Remover for Dogs, Odor Control Formula, Refill, 1.33 Gal

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•TOUGH ON STAINS AND ODORS: This stain and odor remover is tough on dog urine, feces, vomit, drool and other organic stains and odors.
•MULTI-SURFACE USE: When used and stored as directed, this product is safe for use on carpets, hard floors, furniture, fabrics and more.
•SAFE FOR PETS AND HOME: We’ve been loved by pet parents for over 35 years, so we know the importance of having an effective stain and odor remover that, when used and stored as directed, is safe to use around pets.
•CITRUS SCENT: In addition to removing stains and odors, this product freshens with a light citrus scent.

View offer on:

$27.45

$32.49

-16%

Check Price

Nature's Miracle

Nature's Miracle Dog Stain and Odor Remover, Everyday Mess Enzymatic Formula, 24 fl oz

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•SPOT STAIN & ODOR REMOVER: Begins to break down and remove stains immediately on contact.
•LIGHT CITRUS SCENT: Dog odor control formula gets your home smelling clean again.
•ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
•SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets.
•TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works.

View offer on:

$8.97

$10.99

-18%

Check Price

Resolve

Resolve Pet Expert Stain and Odor Remover, Carpet Cleaner, Pet Stain and Odor Remover, Carpet & Upholstery Cleaner - Removes Stains and Odors, 22 oz (pack of 1)

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•Stain & odor remover that provides amazing stain removal the 1st time!
•Works great on everyday stains like red wine, grape juice, and greasy food.
•Discourages pet resoiling.
•Great for: pet urine, pet feces, pet vomit.
•Safe to use around pets and kids.

View offer on:

$5.97

Check Price

Theochem

Theochem I Love My Pet Bio-Enzyme Stain and Odor Eliminator for Home, Enzyme Cleaner, Pet Carpet Cleaner Spray, Pee, Carpet Stain Remover Spray, 32 oz Fresh Scent

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•BIO ENZYMATIC ACTION: Professional strength enzyme cleaner breaks down cat urine, dog poop, blood, and vomit, removes tough stains and odors
•DEEP ODOR AND STAIN REMOVER: Penetrates fibers and padding; tackles set in smells and discoloration; helps reduce remarking on treated areas
•MULTI SURFACE SAFE: For carpet, rugs, upholstery, couches, mattresses, sealed hardwood, tile, grout, concrete, trash cans, and car interiors
•SAFE & NON-TOXIC: Made with natural, eco-friendly and biodegradable ingredients safe for pets, children, carpets, upholstery, and hard surfaces
•OVERNIGHT SENSATION: For set-in and older stains, naturally breaks down stains and odors while you sleep, leaving your home fresh and clean
•FRESH SCENT: Pleasant scent leaves your home smelling clean and refreshing, neutralizing pet odors without overpowering fragrances
•EASY TO USE: Simply spray, wait, and blot or wipe away; no scrubbing required for fast and effective results
•HELPS PREVENT RE-SOILING: By completely eliminating the source of the odor, our cleaner removes the markers that attract pets back to the same spot, aiding in house-training and preventing future accidents
•FIELD-TESTED FOR REAL RESULTS: Tough on stains yet safe for everyday use, our cleaners are battle-tested in real homes and businesses to deliver fast, reliable results
•COMMITTED TO A CLEANER WORLD: As industry leaders, we're dedicated to safe, innovative formulas that make life simple and superior for everyday use, tailored to protect what matters most

View offer on:

$22.49

Check Price

📊

📈 How we rank

With our cutting-edge technology, we examine thousands of products and retailers, assessing reviews, ratings, trends, and sales rankings to identify what matters most to users like you.

Our team evaluates this data alongside genuine user feedback, merging AI analysis with human insights to provide you with real-time, highly-rated recommendations that empower your decision-making with clarity and confidence.