Top 10 Best enzyme cleaners in 2026

Last Updated - 6/16/2026

🏆Best Choice

Rocco & Roxie Supply Co.

Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
•Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
•Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
•Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
•Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it rightx

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$23.92

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Rocco & Roxie Supply Co.

Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover, Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray for Home, Puppy Potty Training

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•Eliminates Stains, Odors, & Residue: If it’s gross, it’s gone; from blowouts, urine, vomit, and other organic spills; Rocco & Roxie stain & odor eliminator has a subtle Meyer lemon scent that quickly dissipates, leaving your space feeling fresher
•Every Surface, Every Time: Our fast-acting carpet stain remover spray formula works great on floors, furniture, clothing, pet bedding, litter boxes, travel crates, hamster cages, cars, campers, and anywhere else major accidents happen
•Minerals & Enzymes: The key is getting to the problem deep-down, so we added a mineral-based odor neutralizer to our bio-enzymatic formula; upon contact with tough stains & odors, this pet enzyme cleaner feasts on ammonia crystals and organic matter
•Gentle & Safe Carpet Spray: Safe to use around pets and children, when used as directed; chlorine-free, color-safe with no hazardous propellants; Certified Safe for all carpets with the Seal of Approval by the trusted Carpet and Rug Institute (CRI)
•Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this pet odor eliminator and stain remover, contact us; we are determined to make it right

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$27.97

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Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray, 1-Gallon

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
•Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
•Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
•Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
•Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it right

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$59.97

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KINZUA ENVIRONMENTAL

KINZUA ENVIRONMENTAL Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Original Scent, 1 Gallon

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•Powerful & Effective Cleaner: Each gallon of Urine B-Gone is loaded with 200 billion microbe colonies, working tirelessly to liquefy, digest, and eliminate urine and poop; This high-strength formula ensures your home stays fresh and free from unpleasant odors
•Deep Penetration, Lasting Results: Urine B-Gone doesn’t just mask odors; it attacks them at the source; This powerful enzyme cleaner penetrates deep into any carpet and upholstery, removing stains and neutralizing smells even from padding and the floor beneath; Its versatile formula makes it suitable for all cleaning tasks, ensuring every surface is left fresh and spotless
•Safe for Your Home: Our natural enzyme formula is safe to use around pets and children when used as directed; It’s designed to be gentle yet highly effective, providing peace of mind while maintaining a clean and odor-free environment; Enjoy the fresh scent of our urine cleaner
•Versatile Cleaning Solution: Beyond pet stains, Urine B-Gone is ideal for a variety of applications; Use it in your laundry to pre-spray soiled areas or even in drains, urinals, and toilets; This all-in-one cleaner & odor remover makes tackling tough stains and odors simple and efficient
•About Us: At Kinzua Environmental, we specialize in premium cleaning solutions that are safe and professional strength for both commercial and household applications

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$34.45

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Zeiff

Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 32 Ounce - Fragrance Free

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•Pro Grade Clean - Zeiff Pro-Grade Formulas are innovative, unique proprietary solutions, trusted by professionals and consumers for being the most effective cleaning products to get the job done. Whether you’re a pro or just expect pro-grade results, Zeiff delivers Pro Grade Clean
•Powerful Cleaning Performance - Our proprietary formulation breaks up complex organic proteins, pet stains, hair, grease, fats, and oils, easily cutting through dirt, grease and grime without leaving any visible residue. Don't just expect clean, expect Zeiff Clean! You'll know it when you see it, clean you didn't even know exists
•Multi-Purpose Enzyme Cleaner - The special blend of bacterial enzymes, detergent and deodorant, prevents clogging in drains, grease traps, septic tanks, drain lines and downpipes, and cleans stains, odors, carpets, floors, kitchen & bathroom surfaces, and much more. Ideal for Professional and Home use
•Deodorizer & Odor Eliminator - Highly concentrated bacterial digestant for grease, stains, oils, & organic waste. Effectively eliminates foul odors caused by urine, feces, blood, vomit, food, garbage and grease, leaves long-lasting freshness
•Safe & Effective - Zeiff Pro Grade Formulas are safe & effective, non-corrosive, non-flammable, non-acidic, free of caustics and dyes, pH neutral, paraben-free, pet safe, cruelty-free. Proudly made in the USA

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$11.77

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Zeiff

Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner - Pet Stain and Odor Remover, Drain Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 32 Ounce

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•Pro Grade Clean - Zeiff Pro-Grade Formulas are innovative, unique proprietary solutions, trusted by professionals and consumers for being the most effective cleaning products to get the job done. Whether you’re a pro or just expect pro-grade results, Zeiff delivers Pro Grade Clean
•Powerful Cleaning Performance - Our super strength proprietary formulation breaks up and digests complex organic proteins, pet stains, hair, grease, fats, and oils, easily cutting through dirt, grease and grime without leaving any visible residue. Don't just expect clean, expect Zeiff Clean! You'll know it when you see it, clean you didn't even know exists
•Multi-Purpose Enzyme Cleaner - The drain odor eliminator is a special blend of powerful bacterial enzymes, detergent and deodorant, that prevents clogging in drains, garbage disposals, grease traps, sinks, toilets, urinals, septic tanks, drain lines and downpipes. The floor and carpet stain remover cleans stains, odors, carpets, upholstery, fabric, laundry, floors, hardwood, laminate, kitchen & bathroom surfaces, and much more. Ideal for Professional and Home use
•Deodorizer & Odor Eliminator - The dog enzyme cleaner and pet odor eliminator for home is a highly concentrated bacterial digestant for grease, stains, oils, & organic waste. The pet urine enzyme cleaner effectively eliminates foul odors caused by urine, feces, blood, vomit, food, garbage and grease, leaves long-lasting freshness, with a subtle fresh breeze that instantly refreshes any space with a pleasant aroma, great pet enzyme urine cleaner and cat odor eliminator
•Safe & Effective - Zeiff Pro Grade Formulas are safe & effective, non-corrosive, non-flammable, non-acidic, free of caustics and dyes, pH neutral, paraben-free, pet safe, cruelty-free. Proudly made in the USA

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$11.77

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Zeiff

Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner - Pet Stain and Odor Remover, Drain Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 32 Ounce

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•Pro Grade Clean - Zeiff Pro-Grade Formulas are innovative, unique proprietary solutions, trusted by professionals and consumers for being the most effective cleaning products to get the job done. Whether you’re a pro or just expect pro-grade results, Zeiff delivers Pro Grade Clean
•Powerful Cleaning Performance - Our super strength proprietary formulation breaks up and digests complex organic proteins, pet stains, hair, grease, fats, and oils, easily cutting through dirt, grease and grime without leaving any visible residue. Don't just expect clean, expect Zeiff Clean! You'll know it when you see it, clean you didn't even know exists
•Multi-Purpose Enzyme Cleaner - The drain odor eliminator is a special blend of powerful bacterial enzymes, detergent and deodorant, that prevents clogging in drains, garbage disposals, grease traps, sinks, toilets, urinals, septic tanks, drain lines and downpipes. The floor and carpet stain remover cleans stains, odors, carpets, upholstery, fabric, laundry, floors, hardwood, laminate, kitchen & bathroom surfaces, and much more. Ideal for Professional and Home use
•Deodorizer & Odor Eliminator - The dog enzyme cleaner and pet odor eliminator for home is a highly concentrated bacterial digestant for grease, stains, oils, & organic waste. The pet urine enzyme cleaner effectively eliminates foul odors caused by urine, feces, blood, vomit, food, garbage and grease, leaves long-lasting freshness, with a subtle citrus breeze that instantly refreshes any space with a pleasant aroma, great pet enzyme urine cleaner and cat odor eliminator
•Safe & Effective - Zeiff Pro Grade Formulas are safe & effective, non-corrosive, non-flammable, non-acidic, free of caustics and dyes, pH neutral, paraben-free, pet safe, cruelty-free. Proudly made in the USA

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$11.77

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ACTIVE

Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•Powerful Bio Enzymatic Cleaner: ACTIVE Laundry Odor Removers Boost your normal laundry detergent to effectively target Stains & Odors, not mask them like washing soda or in-wash scent boosters. It uses Lab-proven Biological Cleaning to remove laundry odor & strong smell
•Heavy Duty Stain Remover for clothes: Our Enzyme Laundry Additive Powder is formulated for Stain Removal of dirty clothes, perfect for Funk, Grease, Armpit Sweat stain, Blood stain, Oil and more!
•Gentle on All Fabrics: Our Fragrance Free Laundry Boost Plant-based Formula uses zero harsh chemicals. Natural enhancer for whites & colors. Even safe for pesky activewear fabrics
•Value 64 Load Package: ACTIVE Enzyme Cleaner Concentrated 32-oz size is good for 64 Loads compared to other products with 1 lb or less
•Compatible with all Washers & Detergents: Add Laundry Booster Powder to your usual detergent & cleaners! HE, Front & Top load Washer Approved. Also use as laundry soak pretreat powder in order to treat set-in stain

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$19.99

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Biokleen

Biokleen Bac-Out Enzyme Stain & Odor Remover - 128 Ounces - Destroys Stains & Odors Safely, for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•STAIN AND ODOR REMOVER: Bac-Out safely works wonders on pet accidents, wine spills on carpets and couches, cloth diapers and pails, laundry, disposals, garbage cans and much more.
•PREFERRED BY PROFFESSIONALS: Bac-Out is the preferred choice of commercial carpet cleaners nationwide.
•BIO ACTIVE FORMULA: A unique blend of live enzyme cultures breakdown and absorb organic material. It's a more natural way to remove buildup and stinky odors.
•PLANT BASED CLEANER: Bac-Out uses a plant-based, eco-friendly solution with no artificial fragrances or dyes. Our products never contain phosphates, chlorine, ammonia, or brighteners.
•MADE IN THE USA: We use biodegradable ingredients, never test on animals, and are manufactured in the USA with US and imported parts

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$34.98

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Nanoskin

Nanoskin ENZYME Multi-Purpose Cleaner & Odor Eliminator 1 Gallon - Removes Complex Organic Stains, Dirt, Grease, and Grime from Multi Surfaces | For Automotive, Floor, Kitchen, Bathroom, Plumbing

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•✅ COMBAT ORGANIC MESSES : Enzyme cleaner emits enzymes to break down molecules found in organic material like grass, blood, urine, vomit feces, and food. Once it breaks the molecules down into smaller pieces, the raising agent swoops in to consume those molecules.
•✅ MULTI-PURPOSE: Proprietary blend of enzymes breaks up complex organic proteins, pet stains, hair, grease, fats, and oils, easily cutting through dirt, grease, and grime without leaving any visible residue. Don't just expect clean, expect Enzyme Clean!
•✅ MULTI-SURFACE: Nanoskin Enzyme has a special blend of beneficial enzymes, detergent, and deodorant, prevents clogging in drains, grease traps, septic tanks, drain lines, and downpipes and cleans stains, odors, carpets, floors, kitchen & bathroom surfaces, and much more. Ideal for professional detailer and home use.
•✅ ELIMINATE FOUL ODORS: Effectively eliminates foul odors caused by urine, feces, blood, vomit, food, garbage, and grease and leaves long-lasting freshness. Nanoskin Enzyme is fragrance free with no artificial fragrance to cover the odor. Safe to use around pets and children.
•✅ EASY & SAFE TO USE: Ready-to-Use formula. Nanoskin Enzyme is formulated to be safe & effective, non-corrosive, non-flammable, non-acidic, free of caustics and staining dyes, pH neutral, paraben-free. Unique proprietary solutions, trusted by professionals and consumers.

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$19.93

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