Top 10 Best enzyme stain remover in 2026

Last Updated - 6/18/2026

🏆Best Choice

Miss Mouth's

Miss Mouth's Messy Eater Stain Treater Spray - 4oz 2 Pack Stain Remover - Newborn & Baby Essentials - No Dry Cleaning Food, Grease, Coffee Off Laundry, Underwear, Fabric

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•POWERFUL & FAST WORKING This lightning fast laundry stain remover spray is perfect for clothes, upholstery, and carpets.
•SAFER CHOICE CERTIFIED Our stain remover is proudly EPA Safer Choice certified, giving you peace of mind that it meets your high standards for health and safety. Miss Mouth’s Messy Eater Stain Treater formula gets the job done while being a safer choice for you and your family.
•WORKS MAGIC ON STAINS This stain remover for baby clothes is great for infants, toddlers, and adults and is effective on both fresh and set-in stains. Works on fruit juice, baby food, formula, ketchup, blowouts, and even blood.
•EASY TO USE: First, ditch the excess gunk and dampen dry stains with a splash of water. Spray on Miss Mouth’s, give it a little rub if needed, then toss it in the wash or clean as usual. Still see the stain? Hit repeat. Easy peasy.

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$15.14

$17.99

-16%

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Rocco & Roxie Supply Co.

Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
•Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
•Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
•Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
•Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it rightx

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$23.92

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Puracy

Puracy Stain Remover Spray, Natural Based Travel and Laundry Stain Cleaner for Clothes, Baby Essentials, Kids Stains, Oil and Fabric Spot Cleaner (Unscented, 12 oz)

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•Gentle Yet Mighty Stain Remover - Puracy cleaning spray is meticulously crafted to gently yet powerfully tackle fresh and set-in stains. Ideal for unexpected moments, it efficiently removes stains, preserving the beauty of your cherished garments.
•Harmonious Stain and Odor Solution - Trust our stain remover for clothes to gracefully handle a range of stains and odors. Whether it's grass, red wine, makeup, or oil, our refreshing formula ensures your clothes look and smell as wonderful as you.
•Kind to All Fabrics - Designed for universal use, Puracy stain remover delicately cares for a spectrum of fabric types. It's your trusted companion for maintaining the pristine condition of everything from delicate linens to robust upholstery.
•Free From Harsh Chemicals - Our stain remover ensures a pristine clean without the compromise. Formulated without sulfates, parabens, bleaches, or petrochemicals, it's a worry-free choice for every household, safeguarding both your loved ones and the environment.
•Expertly Crafted with Care - Behind every bottle is a team of chemists and PhDs who prioritize your family's safety. Using only mineral and plant-based ingredients, our stain remover ensures peace of mind for homes with little ones and furry friends.

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$13.99

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Puracy

Puracy Stain Remover Cleaning Spray Refill - Enzyme-Powered Stain Remover Spray As Seen on TikTok, Natural Travel Spot Removal for Clothes (Unscented, 48 fl oz)

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•Gentle Yet Mighty Stain Remover - Puracy cleaning spray is meticulously crafted to gently yet powerfully tackle fresh and set-in stains. Ideal for unexpected moments, it efficiently removes stains, preserving the beauty of your cherished garments.
•Harmonious Stain and Odor Solution - Trust our stain remover for clothes to gracefully handle a range of stains and odors. Whether it's grass, red wine, makeup, or oil, our refreshing formula ensures your clothes look and smell as wonderful as you.
•Kind to All Fabrics - Designed for universal use, Puracy stain remover delicately cares for a spectrum of fabric types. It's your trusted companion for maintaining the pristine condition of everything from delicate linens to robust upholstery.
•Free From Harsh Chemicals - Our stain remover ensures a pristine clean without the compromise. Formulated without sulfates, parabens, bleaches, or petrochemicals, it's a worry-free choice for every household, safeguarding both your loved ones and the environment.
•Expertly Crafted with Care - Behind every pack is a team of chemists and PhDs who prioritize your family's safety. Using only mineral and plant-based ingredients, our stain remover ensures peace of mind for homes with little ones and furry friends.

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$29.99

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SHOUT

Shout Active Enzyme Laundry Stain Remover Spray, Triple-Acting Formula Clings, Penetrates, and Lifts 100+ Types of Everyday Stains - Prewash Spray 22oz

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•What You'll Get: One 22oz spray bottle of Shout's Prewash Active Enzyme Stain Remover Spray. Bottle, excluding trigger & label, made of 25% Post Consumer Recycled plastic!
•Everyday formula: works on a wide range of stains from food, drinks, makeup, grass, dirt, red wine, blood, and more
•Clings, Penetrates, & Lifts: 50x more concentrated than in-wash powered when applied directly to stain
•Quick & Easy To Use: works on all machine-washable whites and colored fabrics, and works in all water temperatures and in HE and standard washers
•Spray, Rub, and Wash: our formula let's you treat the toughest stains and wash up to a week later

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$3.48

$4.04

-14%

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ACTIVE

Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•Powerful Bio Enzymatic Cleaner: ACTIVE Laundry Odor Removers Boost your normal laundry detergent to effectively target Stains & Odors, not mask them like washing soda or in-wash scent boosters. It uses Lab-proven Biological Cleaning to remove laundry odor & strong smell
•Heavy Duty Stain Remover for clothes: Our Enzyme Laundry Additive Powder is formulated for Stain Removal of dirty clothes, perfect for Funk, Grease, Armpit Sweat stain, Blood stain, Oil and more!
•Gentle on All Fabrics: Our Fragrance Free Laundry Boost Plant-based Formula uses zero harsh chemicals. Natural enhancer for whites & colors. Even safe for pesky activewear fabrics
•Value 64 Load Package: ACTIVE Enzyme Cleaner Concentrated 32-oz size is good for 64 Loads compared to other products with 1 lb or less
•Compatible with all Washers & Detergents: Add Laundry Booster Powder to your usual detergent & cleaners! HE, Front & Top load Washer Approved. Also use as laundry soak pretreat powder in order to treat set-in stain

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$19.99

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Biokleen

Biokleen Bac-Out Enzyme Stain & Odor Remover - 128 Ounces - Destroys Stains & Odors Safely, for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•STAIN AND ODOR REMOVER: Bac-Out safely works wonders on pet accidents, wine spills on carpets and couches, cloth diapers and pails, laundry, disposals, garbage cans and much more.
•PREFERRED BY PROFFESSIONALS: Bac-Out is the preferred choice of commercial carpet cleaners nationwide.
•BIO ACTIVE FORMULA: A unique blend of live enzyme cultures breakdown and absorb organic material. It's a more natural way to remove buildup and stinky odors.
•PLANT BASED CLEANER: Bac-Out uses a plant-based, eco-friendly solution with no artificial fragrances or dyes. Our products never contain phosphates, chlorine, ammonia, or brighteners.
•MADE IN THE USA: We use biodegradable ingredients, never test on animals, and are manufactured in the USA with US and imported parts

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$34.98

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ZOUT

Zout Laundry Stain Remover Spray, Triple Enzyme Formula Removes the Toughest Stains, Made in the USA, 22 Ounce Bottles, 2-Pack

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•Powerful Stain Remover: Zout e ectively removes the most challenging stains from clothing, like grass, ground-in dirt, blood, foods, and other set-in stains.
•Triple Enzyme Formula: One enzyme removes protein stains such as blood and grass. The second works on stains like tomato and BBQ sauce and the third targets fat and oil stains like salad dressing and butter.
•Fabric Friendly: This Made in the USA formula can be used on most colorfast washable fabrics.
•How to Use: Saturate the stain completely with the stain remover. Work it thoroughly to penetrate the stain. Wait 5 minutes, then wash as usual. If hand washing, be sure to rinse the garment thoroughly.
•One and Done: Zout removes even the toughest, set-on stains the first time it is used, unlike many other stain-removing products that require multiple treatments and washes.

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$14.99

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ZOUT

Zout Laundry Stain Remover, Triple Enzyme Formula for Blood, Tomato Sauce, & Oil Stains, Made in USA, 12 Ounce Squeeze Bottle with Flip Top Cap

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•Powerful Stain Remover: Zout tackles the toughest stains— blood, tomato sauce, cooking oil, grass, and other set-in messes—with powerful, targeted action
•Triple Enzyme Formula: One enzyme removes protein stains like blood and grass. The second breaks down tomato and BBQ sauce. The third targets oily stains like salad dressing and butter
•Fabric Friendly: Suitable for colorfast washable fabrics. Made in the USA and gentle enough for everyday laundry needs
•Easy to Use: Saturate the stain completely. Work it in thoroughly. Wait 5 minutes, then wash as usual. For handwashing, rinse thoroughly
•One and Done: Removes the most stubborn stains on the first try—no need for multiple treatments like other stain removers

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$5.99

$7.99

-25%

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Biokleen

Biokleen Bac-Out Enzyme Stain Remover - 32 Ounce - Natural Foam Spray, Destroys Stains & Odors Safely, for Pet Stains, Laundry, Diapers, Wine, Carpets, Eco-Friendly, Non-Toxic, Plant-Based

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•Destroys stains and odors safely and naturally with an unique blend of live enzyme cultures, botanicals, and plant-based surfactants
•Full Strength Formula is ready to use - No diluting required
•Eco-Friendly, Non-Toxic, Plant-Based, No Artificial Fragrance, Colors or Preservatives
•Great on pet accidents, wine, diapers, laundry, drains, carpets, and much more
•Kind to those with chemical sensitivities and allergies
•Preferred by commercial carpet cleaners nationwide
•No negative effects on rivers, streams, plants or wildlife
•Made in the USA

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$13.99

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