Top 10 Best nyquil severe cold and flu in 2026

Last Updated - 6/17/2026

🏆Best Choice

Amazon Basic Care

Amazon Basic Care Night Time Cold & Flu Liquid, Cherry, 12 fl oz (Pack of 1)

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENTS: Active ingredients are Acetaminophen 650 mg, Dextromethorphan HBr 30 mg, and Doxylamine succinate, 12.5 mg. Compare to the active ingredients of Vicks NyQuil Cold & Flu
•RELIEVES COLD & FLU SYMPTOMS: Amazon Basic Care Nighttime Cold & Flu Relief provides multi-symptom relief by helping with common symptoms such as aches, fever, cough, sneezing and runny nose
•NIGHTTIME COLD AND FLU RELIEF: Amazon Basic Care Nighttime Cold and Flu Relief relieves cold and flu symptoms so you can rest through the night.
•EFFECTIVE: Acts as a pain reliever, fever reducer, cough suppressant and antihistamine.
•GLUTEN FREE: This product is Gluten Free. Contains 10% ALCOHOL.

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$5.87

$6.29

-7%

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Vicks

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•RELIEF YOU TRUST, DAY & NIGHT. Use non-drowsy DayQuil SEVERE for daytime relief and at night try NyQuil SEVERE for fast relief so you can rest.
•POWERFUL COLD & FLU RELIEF. DayQuil and NyQuil SEVERE temporarily relieve common cold & flu symptoms
•NOTHING WORKS FASTER. Just one dose starts working fast to provide effective cold & flu relief
•PROVEN RELIEF FOR YOUR WORST COLD & FLU SYMPTOMS. Life doesn’t stop when you have a cold. NyQuil and DayQuil SEVERE tackle your most bothersome cold & flu symptom
•WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.

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$19.97

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Amazon Basic Care

Amazon Basic Care Nighttime Severe Cold and Flu Syrup, Max Strength Liquid Medicine, Multi-Symptom Relief, for Adults and Children 12 Years and Older, Mixed Berry Flavor, 12 fl oz (Pack of 1)

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENTS: Contains acetaminophen 650 mg, dextromethorphan HBr 20 mg, doxylamine succinate 12.5 mg, and phenylephrine HCl 10 mg, which compares to the active ingredients in Vicks NyQuil Severe
•MAXIMUM STRENGTH: Amazon Basic Care Nighttime Severe Cold and Flu Relief provides maximum strength relief of headache, fever, sore throat, minor aches and pains, sinus congestion and pressure, sneezing, runny nose and cough
•NIGHTTIME RELIEF: Provides cold care through the night; this cold and flu medicine relieves cold and flu symptoms so you can rest; does not contain pseudoephedrine
•EFFECTIVE: Each dose contains a pain reliever, fever reducer, cough suppressant, antihistamine and nasal decongestant
•MIXED BERRY FLAVOR LIQUID: This liquid cold and flu medicine comes in tasty mixed berry flavor and provides multi-symptom relief; alcohol free, sugar free and gluten free

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$6.75

$7.72

-13%

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Amazon Basic Care

Amazon Basic Care Nighttime Severe Cold & Flu Liquid, Original, 12 fl oz (Pack of 1)

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•ACTIVE INGREDIENTS: Compare to the active ingredients in Vicks NyQuil Severe Cold and Flu, acetaminophen 650 mg, dextromethorphan HBr 20 mg, doxylamine succinate 12.5 mg and phenylephrine HCl 10 mg
•MAXIMUM STRENGTH RELIEF: Each dose includes a pain reliever/fever reducer, cough suppressant, antihistamine and nasal decongestant so you can rest; this medicine also contains ten percent alcohol
•FOR NIGHT TIME USE: Amazon Basic Care Night Time Severe Cold and Flu Relief soothes your severe symptoms to help you sleep
•MULTI-SYMPTOM RELIEF: Temporarily relieves common cold and flu symptoms: fever, minor aches and pains, sore throat, coughing, sneezing, runny nose and sinus pressure
•SOOTHES COLD AND FLU SYMPTOMS: Promotes nasal and/or sinus drainage and temporarily restores freer breathing through the nose; this medicine is sugar free and gluten free; for ages 12 and older

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$6.75

$8.36

-19%

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Amazon Basic Care

Amazon Basic Care Daytime and Nighttime Max Strength Severe Cold and Flu Relief Medicine, Combo Pack, Liquid Medication for Day and Night, Original and Berry, 24 fl oz (Pack of 1)

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•ACTIVE INGREDIENTS: Compare this daytime and nighttime cold medicine to Vicks DayQuil Severe and Vicks NyQuil Severe active ingredients
•DAYTIME RELIEF: Daytime Severe cold medicine contains acetaminophen (pain reliever/fever reducer), dextromethorphan HBr (cough suppressant), guaifenesin (expectorant) and phenylephrine HCl (nasal decongestant) to help you power through the day
•NIGHTTIME RELIEF: Nighttime Severe cold medicine contains acetaminophen (pain reliever/fever reducer), dextromethorphan HBr (cough suppressant), doxylamine succinate (antihistamine) and phenylephrine HCl (nasal decongestant) so you can rest at night
•AROUND THE CLOCK: Relieve symptoms during the day and at night while you sleep with Amazon Basic Care Daytime and Nighttime Severe Cold and Flu Relief
•MAXIMUM STRENGTH: Get maximum strength relief for your severe cold and flu symptoms

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$10.47

$12.72

-18%

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Amazon Basic Care

Amazon Basic Care Nighttime Cold and Flu Relief Softgels, 6 Hour Cold Medicine, Relieves Major Flu Symptoms So You Can Rest, 48 Count (Pack of 1)

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•ACTIVE INGREDIENTS: This product contains acetaminophen (pain reliever and fever reducer), dextromethorphan HBr (cough suppressant) and doxylamine succinate (antihistamine) which compares to the active ingredients in Vicks NyQuil Cold & Flu.
•POWERFUL NIGHTTIME RELIEF: This cold and flu medicine provides multi-symptom relief of common cold and flu symptoms while you sleep.
•PAIN RELIEVER AND FEVER REDUCER: Relieves sore throat, minor aches and pains and reduces fever associated with the common cold and flu.
•COUGH SUPPRESSANT: This nighttime cold and flu relief medicine helps to relieve coughing so you can rest.
•ANTIHISTAMINE: Helps relieve runny nose and sneezing associated with the common cold and flu.

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$12.58

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Vicks

Vicks DayQuil & NyQuil SEVERE Cold & Flu Medicine, Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Nasal Congestion, Sinus Pressure, Stuffy Nose, and Cough, Co-Pack, 2 x 12 OZ

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•Relief You Trust, Day and Night: Use non-drowsy DayQuil SEVERE for powerful daytime relief, and at night, try NyQuil SEVERE for fast-acting comfort so you can rest
•Powerful Cold and Flu Relief: DayQuil and NyQuil SEVERE temporarily relieve common cold and flu symptoms.
•Nothing Works Faster: Just one dose starts working quickly to deliver fast and effective cold and flu relief
•Proven Relief for Your Worst Cold and Flu Symptoms: Life doesn’t stop when you have a cold — NyQuil and DayQuil SEVERE work fast to tackle your most bothersome cold and flu symptoms
•Vicks has been trusted for over 125 years to relieve your worst cold and flu symptoms

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$19.97

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Vicks

Vicks NyQuil Severe Cold, Flu, & Congestion Medicine, 24 Liquicaps, Maximum Strength, 24Count

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•Max Strength multi-symptom relief. Relieves cough, headache, fever, sore throat, minor aches & pains, nasal congestion, sinus pressure, and sneezing & runny nose

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$11.97

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Vicks

Vicks NyQuil SEVERE Cold and Flu Relief Liquid Berry Flavored Medicine, Maximum Strength, 9-Symptom Nighttime Relief For Fever, Sore Throat, Nasal Congestion, Sinus Pressure, Sneezing, Cough, 12 FL OZ

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•POWERFUL, MAXIMUM STRENGTH 9-SYMPTOM RELIEF: NyQuil SEVERE relieves coughing, sneezing, stuffy nose, minor body pain, sinus congestion, sinus pressure, sore throat, headache, and fever
•POWERFUL NIGHTTIME COLD & FLU RELIEF: NyQuil SEVERE temporarily relieves common cold & flu symptoms so you can get the rest you need
•FAST RELIEF SO YOU CAN SLEEP: Don't let your cold keep you up, Just one dose of NyQuil SEVERE starts working fast to provide effective cold & flu relief
•GREAT-TASTING BERRY FLAVORED NYQUIL: Get the same cold & flu relief you expect from NyQuil SEVERE in a berry flavor
•WORLD'S #1 SELLING OTC COUGH AND COLD BRAND** Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms

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$13.99

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Vicks

VICKS NyQuil Cold & Flu Relief Over-the-Counter Medicine, Powerful Multi-Symptom Nighttime Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Sneezing, Runny Nose, and Cough, 48 LiquiCaps

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•POWERFUL MULTI-SYMPTOM RELIEF for your headache, fever, sore throat, minor aches and pains, sneezing, runny nose, and cough.
•EFFECTIVE NIGHTTIME COLD & FLU SYMPTOM RELIEF. NyQuil Cold & Flu Liquicaps temporarily relieves common cold & flu symptoms so you can get the rest you need
•FAST RELIEF SO YOU CAN SLEEP. Don't let your cold keep you up. Just one dose of NyQuil starts working fast to provide effective cold & flu relief
•POWER THROUGH YOUR WORST COLD & FLU SYMPTOMS. Life doesn’t stop when you have a cold. NyQuil relieves bothersome symptoms such as cough and fever so that you can get the rest you need
•WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.

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$28.34

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