Top 10 Best nop in 2026

Last Updated - 6/7/2026

🏆Best Choice

Tylenol

Tylenol PM Extra Strength Nighttime Pain Reliever & Sleep Aid Caplets, 500 mg Acetaminophen & 25 mg Diphenhydramine HCl, Relief for Nighttime Aches & Pains, Non-Habit Forming, 100 ct

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•100-count bottle of Tylenol PM Extra Strength Caplets Nighttime Pain Reliever & NonHabit Forming Sleep Aid to provide minor pain relief and help you fall asleep fast
•Relieve nighttime pain and get the sleep you need with 25 mg diphenhydramine HCl and 500 mg acetaminophen per caplet. This nighttime sleep aid and pain relief medicine is non-habit forming when used as directed
•Fall asleep fast and stay asleep and relieve minor pain with this nighttime sleep aid and pain relief medicine from the #1 doctor-recommended brand for pain relief and fever reduction
•This pain relief sleep aid is intended for use by adults and children who are 12 years of age and older, and is not suitable for younger children or babies
•With Tylenol PM Extra Strength Caplets Pain Reliever plus Sleep Aid, we give you a better night. So you're a better you all day

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$13.97

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Amazon Basic Care

Amazon Basic Care Acetaminophen PM Caplets, Pain Reliever Plus Nighttime Sleep Aid, Extra Strength, Helps Occasional Minor Aches, Pains and Headache Relief, 100 Count, Packaging may vary

9.6

ChoiceComparer.com Score

9.6

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENTS: The active ingredients in Amazon Basic Care Acetaminophen PM are acetaminophen 500 mg, pain reliever, and diphenhydramine HCl 25 mg, nighttime sleep aid. Compare to Extra Strength Tylenol PM Caplets active ingredients
•LESS PAIN, MORE SLEEP: Minor aches & pains can interfere with restful sleep. Amazon Basic Care Acetaminophen PM has 500 mg acetaminophen, pain reliever, and 25 mg of diphenydramine hydrochloride, nighttime sleep aid, together in easy-to-swallow caplets
•USE: Amazon Basic Care Acetaminophen PM may be used as a pain reliever and nighttime sleep aid for adults and children 12 years and over. Child-resistant cap.
•EFFECTIVE SLEEP AID: For pain with sleeplessness. Relieve minor pain with extra-strength Amazon Basic Care Acetaminophen PM nighttime sleep aid medicine which is aspirin free and gluten free.
•NON-HABIT FORMING: Extra strength Amazon Basic Care Acetaminophen PM Caplets are non-habit forming when used correctly.

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$5.97

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Amazon Basic Care

Amazon Basic Care Ibuprofen PM, Ibuprofen 200 mg and Diphenhydramine Citrate 38 mg Tablets, Pain Reliever and Nighttime Sleep-Aid, 120 Count (Packaging may vary)

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENTS: This nighttime pain relief medicine contains ibuprofen 200 mg, a pain reliever (NSAID), and diphenhydramine citrate 38 mg, a nighttime sleep-aid; compare to Advil PM active ingredients
•NIGHTTIME SLEEP AID: Amazon Basic Care Ibuprofen PM contains a combination of a nighttime sleep-aid and a pain reliever (NSAID) that provides relief of occasional sleeplessness when associated with minor aches and painsPAIN RELIEF: Muscles, bones and joints are vulnerable targets for pain to attack; pain may begin with an injury or illness
•FOR ADULTS AND CHILDREN 12 YEARS AND OVER: Amazon Basic Care Ibuprofen PM tablets are used as a pain reliever (NSAID) and sleep aid for adults and children 12 years and over
•GLUTEN FREE: Amazon Basic Care Ibuprofen PM are coated caplets (capsule-shaped tablets) in a safety sealed bottle; this product is gluten free
•Product may be manufactured in India or U.S.

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$11.99

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HealthA2Z

HealthA2Z® Extra Strength Pain Relief PM| Acetaminophen 500mg | Diphenhydramine 25mg | Pain Reliever & Nighttime Sleep Aid | (365 Count (Pack of 1))

9.3

ChoiceComparer.com Score

9.3

/ 10

Excellent

Main highlights

•500 mg Acetaminophen, a proven pain reliever, helps relieve muscle, joint, headache, and arthritis pain quickly.
•25 mg Diphenhydramine, a gentle, non-habit-forming sleep aid, helps you fall asleep and stay asleep while also relieving fever and minor aches and pain with the help of Acetaminophen.
•It contains NO Aspirin
•Adults and children 12 years and over: take 2 caplets at bedtime. Do not take more than 2 caplets of this product per 24 hours/ Children under 12 years do not use.
•No gluten added product

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$14.95

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Advil

Advil PM Liqui-Gels Pain Reliever and Nighttime Sleep Aid, Pain Medicine with Ibuprofen for Pain Relief and Diphenhydramine HCL for a Sleep Aid - 40 Liquid Filled Capsules - Back to College

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•One bottle of 40 liquid filled capsules of Advil PM Liqui-Gels Pain Reliever and Nighttime Sleep Aid, Pain Medicine with Ibuprofen for Pain Relief and Diphenhydramine HCL for a Sleep Aid
•Ibuprofen PM pain medicine helps relieve occasional sleeplessness related to minor aches and pains, and by 2022, new packaging will feature 20% less plastic to keep nearly 500,000 pounds of plastic out of landfills
•Ibuprofen PM sleep aid and pain medication helps you fall asleep and stay asleep
•PM pain reliever that rushes liquid relief right where it hurts
•Headache relief, minor arthritis pain relief, back pain medicine and sleep aid for adults and children 12 years and older - the perfect addition to your college dorm room essentials
•Take two of these Advil pain reliever caplets at bedtime for occasional sleeplessness related to minor aches and pains
•HSA and FSA eligible product

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$7.88

$16.25

-52%

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Excedrin

Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 24 Count

9.0

ChoiceComparer.com Score

9.0

/ 10

Great

Main highlights

•One bottle of 24 Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms
•Migraine medicine that delivers effective migraine headache pain relief
•Delivers migraine relief, including acting as a migraine headache pain reliever and relieving sensitivity to light and sound, and nausea
•Excedrin migraine pain relief caplets combine acetaminophen, aspirin and caffeine
•Delivers a powerful triple action formula with two pain fighters and an amplifier
•Migraine relief medicine available in convenient caplet form
•For some, these Excedrin Migraine caplets relieve migraine pain in 30 minutes
•HSA and FSA eligible product

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$4.97

$7.00

-29%

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RIGHT REMEDIES

Right Remedies Extra Strength Pain Relief PM & Nighttime Sleep Aid Caplets,(300 count), Acetaminophen 500 mg & Diphenhydramine HCl 25 mg, Non-Habit Forming, Compare to Active ingredients of Tylenol PM

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•✅ ACETAMINOPHEN 500 MG : Formulated with active ingredient acetaminophen for temporary relief of minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps
•✅ DIPHENHYDRAMINE HCL 25 MG : Nighttime Pain Reliever & NonHabit Forming Sleep Aid to provide minor pain relief and help you fall asleep fast when used as directed
•✅ EXTRA STRENGTH PAIN RELIEF : Contains 500 mg of acetaminophen is effective, lasting pain reliever and 25 mg of diphenhydramine HCl, is a nighttime sleep aid.
•✅ EASY TO SWALLOW : RIGHT REMEDIES PM Extra Strength Nighttime Pain Reliever Caplets are easy-to-swallow
•✅ COMPARE TO : Active ingredients in Extra Strength Tylenol PM Caplets
•✅ DIRECTIONS : Adults and children 12 years of age and over: take 2 caplets at bedtime. Do not take more than 2 caplets of this product in 24 hours

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$10.44

$10.99

-5%

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Excedrin

Excedrin PM for Headache Relief, Acetaminophen 250mg, Aspirin 250mg, Diphenhydramine Citrate 38mg, Pain Reliever, Nighttime Sleep-Aid, 100 Count

8.7

ChoiceComparer.com Score

8.7

/ 10

Good

Main highlights

•One bottle of 100 Excedrin PM Pain Reliever, Headache Relief and Nighttime Sleep-Aid Caplets
•Pain reliever and nighttime sleeping aid that provides temporary relief of pain associated with headaches and muscle aches accompanied by sleeplessness
•Caffeine-free diphenhydramine, aspirin and acetaminophen caplets are ideal for nighttime headache sufferers
•Nighttime Excedrin caplets that relieve headaches fast to help you get to sleep
•Triple action formula combines two effective pain relievers with a nighttime sleep-aid
•Pain reliever available in convenient caplet form
•Effective headache and muscle pain relief
•HSA and FSA eligible product

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$16.24

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Goody's

Goody's Nighttime Powder, Pain Reliever & Sleep Aid with Acetaminophen & Diphenhydramine Citrate, Caffeine Free, 16 Count

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•Goody’s Nighttime Pain Relief Powder formula works fast to relieve pain and help reduce fever
•Each packet contains 500 mg acetaminophen, 38 mg diphenhydramine citrate, and is caffeine free
•Goody’s Nighttime over-the-counter medication powder comes in convenient, on-the-go stick packs
•Headache relief packets are individually wrapped, making them ideal for travel medicine kits
•Contains 1 box of Goody’s Nighttime Headache Powder, 16 stick powders; for use by adults and children 12 years and older

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$3.94

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With our cutting-edge technology, we examine thousands of products and retailers, assessing reviews, ratings, trends, and sales rankings to identify what matters most to users like you.

Our team evaluates this data alongside genuine user feedback, merging AI analysis with human insights to provide you with real-time, highly-rated recommendations that empower your decision-making with clarity and confidence.