Top 10 Best flea and tick prevention for dogs pill in 2026

Last Updated - 6/25/2026

🏆Best Choice

PetArmor

PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 6 Doses, Waterproof Topical, Fast Acting, Large Dogs Dogs (45-88 lbs)

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•EFFECTIVE, WATERPROOF FLEA TREATMENT FOR DOGS: PetArmor Plus is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
•TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Dogs. PetArmor Plus for Dogs has a powerful formula that starts to kill fleas within 24 hours.
•BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Dog Flea Treatment works by effectively breaking the flea life cycle. Kill flea eggs and larvae to prevent re-infestation.
•FAST ACTNG LONG-LASTING FLEA AND TICK PROTECTION: One application of PetArmor Plus lasts up to 30 days nose to tail. A 6-dose package lasts up to six months.
•EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with six (6) waterproof topical applications that provide your pet flea protection and control for (6) months.

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$39.99

$44.99

-11%

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PetArmor

PetArmor Plus Flea and Tick Prevention for Dogs, Small Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting (5-22 lbs)

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•EFFECTIVE, WATERPROOF FLEA TREATMENT FOR DOGS: PetArmor Plus is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
•TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Dogs. PetArmor Plus for Dogs has a powerful formula that starts to kill fleas within 24 hours.
•BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Dog Flea Treatment works by effectively breaking the flea life cycle. Kill flea eggs and larvae to prevent re-infestation.
•FAST ACTNG LONG-LASTING FLEA AND TICK PROTECTION: One application of PetArmor Plus lasts up to 30 days nose to tail. A 6-dose package lasts up to six months.
•EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with three (3) waterproof topical applications that provides your pet flea protection and control for three (3) months.

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$24.99

$28.99

-14%

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PetArmor

PetArmor Plus for Dogs Flea and Tick Prevention for Dogs, Long-Lasting & Fast-Acting Topical Dog Flea Treatment, 6 Count, small

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•EFFECTIVE, WATERPROOF FLEA TREATMENT FOR DOGS: PetArmor Plus is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
•TRUSTED, VET QUALITY* FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Dogs. PetArmor Plus for Dogs has a powerful formula that starts to kill fleas within 24 hours.
•BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Dog Flea Treatment works by effectively breaking the flea life cycle! Kill flea eggs and larvae to prevent re-infestation.
•FLEA AND TICK PROTECTION: PetArmor Plus for Dogs flea drops protects your furry family members from brown dog ticks, American dog ticks, Lone Star ticks, and deer ticks (which may transmit Lyme disease).
•EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with six (6) waterproof topical applications that provide your pet flea protection and control for six (6) months.

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$39.99

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Seresto

Seresto Large Dog Vet-Recommended Flea & Tick Treatment & Prevention Collar for Dogs Over 18 lbs. | 8 Months Protection

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•Vet-recommended, premium flea & tick protection for dogs & puppies without the price tag
•Long-lasting flea and tick collar kills & repels fleas for 8 continuous months
•Seresto is the #1 veterinarian recommended flea & tick collar*
•Starts working within 24 hours to kill & repel fleas by contact so pests don’t have to bite your dog to die
•Hassle-free, non-greasy, easy-to-use flea & tick protection

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K9 Advantix

K9 Advantix II Medium Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 11-20 lbs. | 2-Mo Supply

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•K9 Advantix II Medium Dog 30-day treatment & prevention protects dogs 11-20 lbs. from fleas, ticks, mosquitoes, biting flies and lice
•Kills fleas within 12 hours of application
•Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
•Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
•No prescription needed

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K9 Advantix

K9 Advantix II Medium Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 11-20 lbs. | 1-Mo Supply

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•K9 Advantix II Medium Dog 30-day treatment & prevention protects dogs 11-20 lbs. from fleas, ticks, mosquitoes, biting flies and lice
•Kills fleas within 12 hours of application
•Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
•Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
•No prescription needed

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$18.98

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TevraPet

TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•COMPARE TO K9 ADVANTIX II: Activate II uses Imidacloprid, Permethrin, and Pyriproxyfen - the same safe, fast acting active ingredients used in Advantix II for Dogs. Includes 4 monthly doses
•ACTIVELY PROTECTS YOUR DOG: Activate II is approved by veterinarians to repel and kill fleas and ticks on contact - before your dog is exposed to bites and potential flea borne illnesses
•STOP INFESTATIONS FAST: Our topical drops prevent infestations by breaking the flea life cycle - our insect growth regulator (IGR) starts killing flea eggs and larvae within 12 hours of application
•EASY TO APPLY: Simply apply to the base of your dog's neck, and the waterproof solution will travel across the skin - providing continuous protection for 30 days per application
•MADE IN AMERICA - RESULTS GUARANTEED: TevraPet Activate II is made to the quality standard we demand for our own pets. We're proud to help you protect your dog with confidence

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$28.47

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Vet Treat

VET TREAT's Flea and Tick Prevention for Dogs Chewables -Made in USA- Natural Dog Flea and Tick Treatment - Oral Flea Pills - Vet Recommended Flea and Tick Chews - All Breeds & Sizes - 120 Soft Treats

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•Flea And Tick Prevention For Dogs: Natural essentials your dog needs in a perfectly balanced formula to boost skin, coat & immune health and prevent fleas & ticks from laying eggs on your dog’s coat.
•Dog Flea And Tick Treatment with Skin & Coat Support : Flax seed + Neem + Coriander for dogs naturally repels flea & tick when used daily. Vet Treat Flea and Tick chews provide additional benefits to your dog's skin & coat health with Vitamin B Blend.
•No Garlic, No Chemicals: All natural and science-backed ingredients. Natural alternative to synthetic pesticides. Dog skin & coat supplement for flea and tick prevention.
•Vet Recommended + Made In U.S.A + Clinically Tested: Made in the U.S.A in an FDA-registered facility by veterinarians and animal nutritionists. Clinically tested for safety by a third-party laboratory in the US.
•Flea & Tick Control For All: Tasty chicken-flavored dog flea and tick repellent chews are safe and effective for all ages, sizes & breeds. We left no dog behind.

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$21.95

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Hartz

Hartz UltraGuard Dual Action Flea & Tick Topical Dog Treatment and Flea and Tick Prevention, 6 Months, 5-14 Pound Dogs 6-count(Pack of 1)

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•KILLS FLEAS & TICKS: Kills fleas, flea eggs, deer ticks, and brown dog ticks on contact – it is important for your pup to have a flea and tick prevention treatment all year round!
•PREVENTS RE-INFESTATION: This topical formula prevents re-infestation by breaking the flea life cycle for up to 30 days.
•FAST ACTING FULL BODY PROTECTION: Active ingredients spread across the skin using your dog’s natural oil to quickly travel across the coat for full body protection from head to tail.
•6 MONTHLY FLEA & TICK TREATMENTS: Contains 6 single dose tubes (1 tube per monthly application) for non-stop protection for up to 6 months. Apply at the base of your dog’s back between the shoulder blades each month.

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$12.34

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TevraPet

FirstAct Plus Flea Treatment for Dogs, Small Dogs 6-22 lbs, 3 Doses, Same Active Ingredients as Frontline Plus Flea and Tick Prevention for Dogs

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•3 MONTHLY DOSES OF FLEA TREATMENT FOR DOGS: Each pack of TevraPet FirstAct Plus contains three (3) topical applicators of waterproof flea medicine for dogs that instantly begins to kill and control fleas and flea eggs, larvae, ticks, and chewing lice - and provides continuous protection for up to 30 days after each application
•VET QUALITY FORMULA, EASY TO USE: FirstAct Plus uses Fipronil and (S)-methoprene - the same safe and effective active ingredients as Frontline Plus for Dogs. This powerful formula starts to kill fleas and ticks within 24 hours. Simply apply the applicator to the skin on the back of your dog’s neck and the formula will migrate through the skin providing whole-body protection
•THE SAME ACTIVE INGREDIENTS AS FRONTLINE - FOR FAR LESS: It's worth repeating: Just like Frontline Plus, FirstAct Plus's powerful active ingredients REPEL and KILL fleas and ticks on contact and stop reinfestations. At TevraPet we firmly believe you shouldn't have to pay the "Brand tax" to protect your dog, and we are committed to providing affordable, veterinarian quality solutions without sacrificing an ounce of safety, effectiveness, or reliability
•BREAK THE FLEA LIFECYCLE - KICK THE ITCH: Unlike other flea and tick repellents that only temporarily suppress pest activity, FirstAct Plus for Dogs kills flea eggs and larvae to stop infestations dead in their tracks and breaking the flea and tick life cycle. With FirstAct Plus your dog spend his or her time enjoying life both indoors and outside - no more worrying about biting bugs
•QUALITY ASSURED, RESULTS GUARANTEED: Every dose of FirstAct Plus is produced at our facility in Germany to the exacting standards we demand for our own pets, and rigorously tested for quality and potency. Every single dose we sell is backed by the TevraPet guarantee - if you (or your dog!) are unsatisfied for any reason simply contact us for courteous assistance and a no-questions asked refund

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$19.97

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