Top 10 Best cortisone cream in 2026

Last Updated - 6/15/2026

🏆Best Choice

Amazon Basic Care

Amazon Basic Care Maximum Strength Hydrocortisone 1 Percent Anti-Itch Cream Plus 10 Moisturizers, 2 ounce (Pack of 1)

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENT: Amazon Basic Care Maximum Strength Hydrocortisone 1 Percent Anti-Itch Cream contains vitamins A, D and E plus aloe, with the active ingredient hydrocortisone 1 percent; compare to Cortizone 10 Plus Maximum Strength active ingredient
•HYDROCORTISONE CREAM: Amazon Basic Care Maximum Strength Hydrocortisone 1 Percent Anti-Itch Cream contains the number one doctor recommended anti-itch active ingredient (of U.S. physicians surveyed by an independent market research firm)
•PLUS 10 SOOTHING MOISTURIZERS: Our hydrocortisone cream is enriched with vitamins A, D and E plus aloe to soothe and moisturize while relieving itch fast
•FOR FAST, POWERFUL RELIEF of itches and rashes due to: eczema; psoriasis; seborrheic dermatitis; poison ivy, oak, and sumac; insect bites; external genital and anal itching; soaps; detergents; cosmetics; jewelry
•KEEP ANTI-ITCH CREAM in your first aid kit and medicine cabinet to make sure you are able to fight itch fast with ultra-moisturizing relief for skin redness, irritation, rashes, inflammation, eczema and psoriasis

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$6.37

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Amazon Basic Care

Amazon Basic Care Maximum Strength Anti-Itch Cream, Hydrocortisone 1 Percent Intensive Healing Formula, Itch Relief For Bug Bites, Eczema, Psoriasis, Poison Ivy, Oak and Sumac, 1 ounce (Pack of 1)

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENT: The active ingredient in this anti-itch cream is hydrocortisone 1 percent; compare to the active ingredient in Cortizone 10 Intensive Healing Formula
•MAXIMUM STRENGTH RELIEF: Hydrocortisone is the number one doctor recommended anti-Itch active Ingredient (of U.S. physicians surveyed by an independent market research firm)
•POWERFUL MEDICINE, FAST RELIEF: Great for relieving itching associated with skin irritation, rashes, inflammation, redness, insect bites, eczema, psoriasis and poison ivy, oak and sumac
•LASTS UP TO 10 HOURS when used as directed; ultra creamy, maximum strength hydrocortisone formula helps heal problem skin; safe for sensitive skin; for adults and children age 2 years of age and older
•INTENSIVE HEALING FORMULA calms, nourishes and hydrates; clinically proven to moisturize for up to 24 hours; features antioxidants, chamomile and Vitamins A, C and E

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$4.11

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Cortizone-10

Cortizone-10 Maximum Strength Intensive Healing Itch Relief Lotion for Eczema, 1% Hydrocortisone, Fast-Acting, Anti-Itch Cream for Minor Skin Irritations, Rashes and Inflammation Due to Eczema, 3.5 oz

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•INCLUDES: One (1) 3.5 oz. tube of Cortizone-10 Maximum Strength* Intensive Healing Itch Relief Lotion for Eczema (*Among topical anti-itch OTCs)
•RELIEVES ITCH: Cortizone-10 helps relieve itch associated with minor skin irritations, rashes, and inflammation due to eczema, psoriasis, seborrheic dermatitis, and more
•MOISTURIZES & RESTORES: Dermatologist-tested formula with seven moisturizers, plus a vitamin and botanical complex made specifically for eczema and itchy dry skin
•ACTIVE INGREDIENT: Formulated with 1% hydrocortisone for maximum-strength itch relief without a prescription
•TRAVEL ESSENTIALS: The perfect addition to first aid kits, camping essentials and travel bags for anytime you need on-the-go relief
•FAST ACTING: Relieves itch in five minutes with 24-hour moisturization that's gentle on skin, fragrance free, and dye free
•DOCTOR RECOMMENDED: Cortizone-10 is the No. 1 doctor-recommended OTC anti-itch brand* and is suitable for adults and children ages 2+ (*2024 IQVIA Study)

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$8.88

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Cortizone-10

Cortizone-10 Maximum Strength Intensive Healing Itch Relief Cream, 1% Hydrocortisone, Fast-Acting, Anti-Itch Cream for Bug Bites, Rash, Eczema, Psoriasis, Poison Ivy, Oak, Sumac & More, 2 oz

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•INCLUDES: One (1) 2 oz. tube of Cortizone-10 Maximum Strength* Intensive Healing Itch Relief Cream (*Among topical anti-itch OTCs)
•RELIEVES ITCH: Cortizone-10 helps relieve itch associated with minor skin irritations, inflammation, and rashes due to eczema, psoriasis, insect bites, seborrheic dermatitis, poison ivy, oak, sumac, and more
•MOISTURIZES & RESTORES: Includes 10 moisturizers, plus vitamins A, C, and E to nourish skin and help restore skin's moisture barrier
•ACTIVE INGREDIENT: Formulated with 1% hydrocortisone for maximum-strength itch relief without a prescription
•TRAVEL ESSENTIALS: The perfect addition to first aid kits, camping essentials and travel bags for anytime you need on-the-go relief
•FAST ACTING: Relieves itch in five minutes with 24-hour moisture that's gentle on skin, fragrance free, and dye free
•DOCTOR RECOMMENDED: Cortizone-10 is the No. 1 doctor-recommended OTC anti-itch brand* and is suitable for adults and children ages 2+ (*2024 IQVIA Study)

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$8.97

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Cortizone 10

Cortizone-10 Maximum Strength Intensive Healing Itch Relief Cream, 1% Hydrocortisone, Fast-Acting, Anti-Itch Cream for Bug Bites, Rash, Eczema, Psoriasis, Poison Ivy, Oak, Sumac & More, 1 oz

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•INCLUDES: One (1) 1 oz. tube of Cortizone-10 Maximum Strength* Intensive Healing Itch Relief Cream (*Among topical anti-itch OTCs)
•RELIEVES ITCH: Cortizone-10 helps relieve itch associated with minor skin irritations, inflammation, and rashes due to eczema, psoriasis, insect bites, seborrheic dermatitis, poison ivy, oak, sumac, and more
•MOISTURIZES & RESTORES: Includes 10 moisturizers, plus vitamins A, C, and E to nourish skin and help restore skin's moisture barrier
•ACTIVE INGREDIENT: Formulated with 1% hydrocortisone for maximum-strength itch relief without a prescription
•TRAVEL ESSENTIALS: The perfect addition to first aid kits, camping essentials and travel bags for anytime you need on-the-go relief
•FAST ACTING: Relieves itch in five minutes with 24-hour moisture that's gentle on skin, fragrance free, and dye free
•DOCTOR RECOMMENDED: Cortizone-10 is the No. 1 doctor-recommended OTC anti-itch brand* and is suitable for adults and children ages 2+ (*2024 IQVIA Study)

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$5.48

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Cortizone 10

Cortizone-10 Maximum Strength Soothing Aloe Itch Relief Cream, 1% Hydrocortisone, Fast-Acting, Anti-Itch Cream for Bug Bites, Rash, Eczema, Psoriasis, Poison Ivy, Oak, Sumac & More, 2 oz

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•INCLUDES: One (1) 2 oz. tube of Cortizone-10 Maximum Strength* Soothing Aloe Itch Relief Cream (*Among topical anti-itch OTCs)
•RELIEVES ITCH: Cortizone-10 helps relieve itch associated with minor skin irritations, inflammation, and rashes due to eczema, psoriasis, insect bites, seborrheic dermatitis, poison ivy, oak, sumac, and more
•ACTIVE INGREDIENT: Formulated with 1% hydrocortisone for maximum-strength itch relief without a prescription
•TRAVEL ESSENTIALS: The perfect addition to first aid kits, camping essentials and travel bags for anytime you need on-the-go relief
•FAST ACTING: Relieves itch in five minutes with a fragrance-free and dye-free formula
•DOCTOR RECOMMENDED: Cortizone-10 is the No. 1 doctor-recommended OTC anti-itch brand* and is suitable for adults and children ages 2+ (*2024 IQVIA Study)

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$8.49

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Amazon Basic Care

Amazon Basic Care Maximum Strength 1% Hydrocortisone Anti-Itch Lotion for Eczema, 3.5 ounce (Pack of 1)

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•ACTIVE INGREDIENT: This product contains hydrocortisone 1%, an anti-itch, which compares to the active ingredient in Cortizone 10 Intensive Healing Lotion.
•CLINICALLY PROVEN TO MOISTURIZE FOR 24 HOURS: Long-lasting healing lotion provides 24 hours of moisture to relieve eczema and itchy, dry skin.
•MAXIMUM STRENGTH intensive healing lotion provides fast, lasting itch relief of minor skin irritations, rashes and inflammation due to eczema.
•LONG-LASTING HEALING LOTION offers fast, long-lasting relief from eczema, an inflammation of the outer layer of your skin that can cause itching, irritation and redness.
•ANTI-ITCH: This maximum strength anti-itch lotion relieves your eczema and itchy, dry skin with maximum strength hydrocortisone, 7 intensive moisturizers, botanicals, and vitamins A, C, & E in a soothing, easy-to-spread lotion.

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$7.43

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Cortizone 10

Cortizone-10 Maximum Strength Ultra Soothing Itch Relief Cream, 1% Hydrocortisone, Fast-Acting, Anti-Itch Cream for Bug Bites, Rash, Eczema, Psoriasis, Poison Ivy, Oak, Sumac & More, 2 oz

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•INCLUDES: One (1) 2 oz. tube of Cortizone-10 Maximum Strength* Ultra Soothing Itch Relief Cream (*Among topical anti-itch OTCs)
•RELIEVES ITCH: Cortizone-10 helps relieve itch associated with minor skin irritations, inflammation, and rashes due to eczema, psoriasis, insect bites, seborrheic dermatitis, poison ivy, oak, sumac, and more
•MOISTURIZES & RESTORES: Includes 10 moisturizers to nourish skin and help restore skin's moisture barrier
•ACTIVE INGREDIENT: Formulated with 1% hydrocortisone for maximum-strength itch relief without a prescription
•TRAVEL ESSENTIALS: The perfect addition to first aid kits, camping essentials and travel bags for anytime you need on-the-go relief
•FAST ACTING: Relieves itch in five minutes and is gentle on skin, fragrance free, and dye free
•DOCTOR RECOMMENDED: Cortizone-10 is the No. 1 doctor-recommended OTC anti-itch brand* and is suitable for adults and children ages 2+ (*2024 IQVIA Study)

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$8.97

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Cortizone 10

Cortizone-10 Maximum Strength Soothing Aloe Itch Relief Cream, 1% Hydrocortisone, Fast-Acting, Anti-Itch Cream for Bug Bites, Rash, Eczema, Psoriasis, Poison Ivy, Oak, Sumac & More, 1 oz

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•INCLUDES: One (1) 1 oz. tube of Cortizone-10 Maximum Strength* Soothing Aloe Itch Relief Cream (*Among topical anti-itch OTCs)
•RELIEVES ITCH: Cortizone-10 helps relieve itch associated with minor skin irritations, inflammation, and rashes due to eczema, psoriasis, insect bites, seborrheic dermatitis, poison ivy, oak, sumac, and more
•ACTIVE INGREDIENT: Formulated with 1% hydrocortisone for maximum-strength itch relief without a prescription
•TRAVEL ESSENTIALS: The perfect addition to first aid kits, camping essentials and travel bags for anytime you need on-the-go relief
•FAST ACTING: Relieves itch in five minutes with a fragrance-free and dye-free formula
•DOCTOR RECOMMENDED: Cortizone-10 is the No. 1 doctor-recommended OTC anti-itch brand* and is suitable for adults and children ages 2+ (*2024 IQVIA Study)

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$5.49

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Dynarex

Dynarex Hydrocortisone Cream 1 Oz Tube, 1 Each.

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•Help Soothe Itchy Skin - Is itching keeping you at night? This 1% hydrocortisone cream may help provide temporary relief from redness, swelling, and itching caused by irritation, bites, and rashes.
•Gentle Relief - The active ingredient hydrocortisone USP 1% is a low-potency topical corticosteroid that works by activating naturally occurring substances on your skin to help calm immune reactions.
•Easy To Apply - Use clean hands to apply a thin layer directly onto the affected area. Do not use it on open cuts, sores, or scabs. It can be applied 2-3 times a day or as directed by a physician.
•Ready To Use - Always keep a packet on hand in case of emergencies. This product is suitable for numerous care applications and is available as 1oz tubes and 0.9g single-use hydrocortisone cream packets.
•Effective First Response - A supply of hydrocortisone lotion is an essential item to have in any home or emergency medical care kit. This product meets USP indicators for quality, purity, and potency.

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$3.40

$3.76

-10%

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