Top 10 Best hand sanitizer refill in 2026

Last Updated - 6/14/2026

🏆Best Choice

Germ-X

Germ-X Advanced Hand Sanitizer with Aloe and Vitamin E, 1 Liter, Less Drying Moisturizing Gel, No Rinse Formula, Pump Bottle

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•Seasonal Change Essential: Keep your hands germ-free this cough and cold season with Germ-X hand sanitizer. When used as directed, it kills 99.99% of many common germs. Convenient for use at home, work, school, or on the go.
•Fast and Effective: Cleaning on the go just got a lot easier. Germ-X Advanced Aloe Hand Sanitizer gel kills 99.99% of germs without water in as little as 15 seconds
•Moisturizing Hand Sanitizer: This pleasant, fresh-smelling and non-drying sanitizing formula is enriched with Aloe and Vitamin E, leaving skin feeling soft and moisturized with no sticky residue
•Clear Gel Formula: This USP-grade alcohol-based liquid hand sanitizer is the perfect convenient alternative to soap and water to leave your hands feeling smooth and fresh
•X Germs with Confidence: We make Germ-X products that go wherever you go. From convenient pumps, flip-top caps, sprays, and even wipes, Germ-X products have you covered
•Formula Made in the USA: The makers of Germ-X products have been helping happy, healthy families since 1997

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$5.82

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Germ-X

Germ-X Advanced Hand Sanitizer, 34 Fl Oz (1 Liter), Less Drying Moisturizing Clear Gel, No Rinse Formula, Large Family Size Pump Bottle

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•Seasonal Change Essential: Keep your hands germ-free this cough and cold season with Germ-X hand sanitizer. When used as directed, it kills 99.99% of many common germs. Convenient for use at home, work, school, or on the go.
•Fast and Effective: Hand sanitizing on the go just got a lot easier. Germ-X Advanced Hand Sanitizer gel with aloe kills 99.99% of many common germs without water in as little as 15 seconds
•Moisturizing Hand Sanitizer: This pleasant, fresh-smelling and non-drying hand sanitizing formula is enriched with moisturizers to help leave skin feeling soft and moisturized with no sticky residue
•Clear Gel Formula: This USP-grade 70% alcohol-based hand sanitizer is the perfect convenient alternative to soap and water. The less-drying formula leaves your hands feeling smooth and smelling great
•X Germs with Confidence: We make Germ-X products that go wherever you go. From convenient pumps, flip-top caps, sprays, and even wipes, Germ-X products have you covered
•Formula Made in the USA: The makers of Germ-X products have been helping happy, healthy families since 1997

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$5.82

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Purell

PURELL Advanced Hand Sanitizer Refreshing Gel, Clean Scent, 1 Liter Pump Bottle (Pack of 1) - 9632-04-CMR

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•Show you care about well-being with PURELL Advanced Hand Sanitizer Refreshing Gel, which eliminates 99.99 percent of germs on hands
•Features a refreshing clean scent and evaporates quickly for easy, convenient sanitizing when soap and water aren’t available
•Mild formula and a blend of four moisturizers means hands feel soft even with frequent use; it’s free of triclosan, parabens, phthalates, and preservatives so it doesn’t dry out or irritate skin
•Place these 1-Liter PURELL pump bottles in high-traffic areas where frequent hand sanitization is needed, including classrooms, office reception areas, breakrooms, and large indoor or outdoor events
•Case Includes: 1 – PURELL Advanced Hand Sanitizer Refreshing Gel for Workplaces, 1-Liter pump bottle

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$15.99

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Purell

PURELL Advanced Hand Sanitizer Gel, Clean Scent, 1200 mL Refill for PURELL ES6 Automatic Hand Sanitizer Dispenser (Pack of 2) - 6463-02

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•69% of people expect to see PURELL Hand Sanitizer in public places; show you care about cleanliness and well-being in your facility with this PURELL Advanced Hand Sanitizer Gel refill for the ES6 Dispenser
•Ounce for ounce outperforms other leading hand sanitizers and is proven to kill 99.99% of most common germs that may cause illness
•Formulated with conditioners that are clinically proven to maintain skin health and keep hands feeling soft and healthy even after multiple uses; features a refreshing clean scent
•Each PURELL Hand Sanitizer refill comes with a factory-sealed nozzle that eliminates the risk of contamination and ensures an effective formula that is safe and pleasant to use
•Case Includes: 2 – PURELL Advanced Hand Sanitizer Gel, 1200 mL Refills for the ES6 Automatic Hand Sanitizer Dispenser. ES6 dispensers (6420-01, 6424-01) are sold separately
•This product is manufactured by a certified Women-Owned Business

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$44.83

$59.22

-24%

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Purell

Purell 64 Oz. Advanced Instant Hand Sanitizer Gel Refill

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•The PURELL Advanced Hand Sanitizer Refreshing Gel is the preferred brand that is used by hospitals, and it is preferred by healthcare workers.

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$28.90

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Purell

Purell Advanced Hand Sanitizer Refreshing Gel, Clean Scent, 2-Liter Pump Bottle (Pack of 1). 9625-04

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•Show you care about well-being with PURELL Advanced Hand Sanitizer Refreshing Gel, which eliminates 99.99 percent of germs on hands
•Features a refreshing clean scent and evaporates quickly for easy, convenient sanitizing when soap and water aren’t available
•Mild formula and a blend of four moisturizers means hands feel soft even with frequent use; it’s free of triclosan, parabens, phthalates, and preservatives so it doesn’t dry out or irritate skin
•Place these 2-liter PURELL pump bottles in high-traffic areas where frequent hand sanitization is needed, including classrooms, office reception areas, breakrooms, and large indoor or outdoor events
•Case includes: 1 – PURELL Advanced Hand Sanitizer Refreshing Gel, 2-liter pump bottle

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$28.99

$37.80

-23%

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Purell

Purell Advanced Hand Sanitizer Refreshing Gel, Clean Scent, 1.5 Liter Pump Bottle (Pack of 1) - 5015-04

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•Show you care with PURELL Advanced Hand Sanitizer Refreshing Gel, America’s no. 1 brand of hand sanitizer; just one squirt kills as many germs as two squirts of any other national brand
•Offering PURELL products can positively impact your business image. In fact, 84% of people expect hand sanitizer to be offered in public places
•Mild formula and a blend of four skin conditioners means hands feel soft even with frequent use; it's free of triclosan, parabens, phthalates, and preservatives, so it's gentle on skin
•Place these 1.5 liter PURELL pump bottles in high-traffic areas where frequent hand sanitization is needed, including classrooms, office reception areas, breakrooms, and outdoor events
•Case Includes: 1 – PURELL Advanced Hand Sanitizer Refreshing Gel, 1.5 Liter pump bottles
•This product is manufactured by a certified Women-Owned Business

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$22.59

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PURELL

PURELL Advanced Hand Sanitizer Naturals with Plant-Based Alcohol, Citrus Scent, 1 Liter Pump Bottle (Pack of 1) - 3280-04-CMR

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•Help your family and those you care about kill germs on their hands with PURELL Advanced Hand Sanitizer Naturals, made with naturally derived alcohol
•Proven to kill germs with 2x sanitizing strength
•ECOLOGO certified with essential oils and natural skin conditioners and is free of triclosan, parabens, phthalates, and other unnecessary ingredients
•Large one-liter bottle is ideal for frequent hand sanitizing, like in homes, schools, and offices—or use it to refill PURELL Aluminum Hand Sanitizer Bottles (sold separately, SKU 3282-12KIT-EC)
•Case Includes: (1) 1 Liter PURELL Advanced Hand Sanitizer Naturals with Pump Included
•PURELL Advanced Hand Sanitizer is proven effective through tests conducted by independent third-party laboratories on real hands. Trust in our science-based products.

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$19.61

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Purell

Purell Advanced Hand Sanitizer Gel, 1200 mL Sanitizer Refill TFX Touch-Free Dispenser (Pack of 4) - 5456-04

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•Show you care about the well-being of your team and visitors
•Place PURELL hand sanitizer at desks, in common areas, and restrooms
•The No. 1 hand sanitizer most used by hospitals and proven to kill 99.99 percent of most germs that may cause illness, without damaging skin, even after repeated uses
•Perfect for frequent use. Mild formula with 4 moisturizers is free of triclosan, parabens, phthalates, and preservatives; so it does not dry out or irritate skin. Hands feel soft, even after many uses
•PURELL Advanced Sanitizer Refill works with the PURELL TFX Touch-Free Dispenser to help eliminate germs. Each 1200 mL refill holds up to 1000 uses
•Includes 4 - 1200 mL PURELL Advanced Hand Sanitizer Gel Refills, compatible with PURELL TFX Touch-Free Hand Sanitizer Dispensers, 2720-12, 2780-12. Dispenser sold separately

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$74.81

$81.64

-8%

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Purell

Purell Advanced Hand Sanitizer Gel ES1 Push-Style Hand Sanitizer Dispenser, 450 mL refill bottle (Pack of 6) – 4450-06

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•Ensure hand sanitizer is available wherever soap and water aren’t with PURELL Advanced Hand Sanitizer
•America’s No. 1 brand of hand sanitizer kills 99.99 percent of common germs that may cause illness
•AT-A-GLANCE design quickly shows you how much product is left. Once the bottle is empty, take it out, throw it in the recycling, and snap in a new one in seconds
•Compatible with the PURELL ES1 Manual Hand Sanitizer Dispensers, our most compact dispenser designed for locations with limited space
•Case includes: 6 – PURELL Advanced Hand Sanitizer Gel for ES1 Manual Hand Sanitizer Dispenser

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$48.00

$56.33

-15%

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With our cutting-edge technology, we examine thousands of products and retailers, assessing reviews, ratings, trends, and sales rankings to identify what matters most to users like you.

Our team evaluates this data alongside genuine user feedback, merging AI analysis with human insights to provide you with real-time, highly-rated recommendations that empower your decision-making with clarity and confidence.