Top 10 Best anti itch in 2026

Last Updated - 6/15/2026

🏆Best Choice

Amazon Basic Care

Amazon Basic Care Maximum Strength Anti-Itch Cream, Hydrocortisone 1 Percent Intensive Healing Formula, Itch Relief For Bug Bites, Eczema, Psoriasis, Poison Ivy, Oak and Sumac, 1 ounce (Pack of 1)

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENT: The active ingredient in this anti-itch cream is hydrocortisone 1 percent; compare to the active ingredient in Cortizone 10 Intensive Healing Formula
•MAXIMUM STRENGTH RELIEF: Hydrocortisone is the number one doctor recommended anti-Itch active Ingredient (of U.S. physicians surveyed by an independent market research firm)
•POWERFUL MEDICINE, FAST RELIEF: Great for relieving itching associated with skin irritation, rashes, inflammation, redness, insect bites, eczema, psoriasis and poison ivy, oak and sumac
•LASTS UP TO 10 HOURS when used as directed; ultra creamy, maximum strength hydrocortisone formula helps heal problem skin; safe for sensitive skin; for adults and children age 2 years of age and older
•INTENSIVE HEALING FORMULA calms, nourishes and hydrates; clinically proven to moisturize for up to 24 hours; features antioxidants, chamomile and Vitamins A, C and E

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$4.11

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Benadryl

Benadryl Extra Strength Anti Itch Relief Gel, 2% Diphenhydramine HCl, Relief from Insect Bites, Sunburn & More, Great for Camping Essentials, 3.5 fl oz

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•ANTI ITCH GEL: Benadryl anti itch gel temporarily provides pain and itch relief associated with insect bites, minor burns, sunburn, minor skin irritation, minor cuts and scrapes, and rashes due to poison ivy and poison sumac.
•TOPICAL ANALGESIC: Topical cooling gel contains 2% of the topical analgesic pain reliver diphenhydramine hydrochloride that helps to relieve itches and minor pains on the skin; Provides relief from most outside itches.
•SOOTHING and COOLING GEL: Carry this topical anti itch analgesic gel to relieve uncomfortable skin irritation at home or on the go; Works when you need it most and provides cooling relief from minor pain to intolerable itchy skin.
•POISON IVY REIEF: Topical Analgesic to provide itch relief for most outdoor itches associated with poison ivy, insect bites; Dries the oozing and weeping of poison ivy, poison oak and poison sumac.
•INCLUDES: Pack of 1, 3.5 fl. oz. anti itch gel; Suitable for adults and children ages 2 plus; Provides itch relief for kids and adults alike and great to keep on hand during outdoor activities such as camping, hiking, or walking with the family.

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$6.22

$8.46

-26%

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Cortizone-10

Cortizone-10 Maximum Strength Intensive Healing Itch Relief Cream, 1% Hydrocortisone, Fast-Acting, Anti-Itch Cream for Bug Bites, Rash, Eczema, Psoriasis, Poison Ivy, Oak, Sumac & More, 2 oz

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•INCLUDES: One (1) 2 oz. tube of Cortizone-10 Maximum Strength* Intensive Healing Itch Relief Cream (*Among topical anti-itch OTCs)
•RELIEVES ITCH: Cortizone-10 helps relieve itch associated with minor skin irritations, inflammation, and rashes due to eczema, psoriasis, insect bites, seborrheic dermatitis, poison ivy, oak, sumac, and more
•MOISTURIZES & RESTORES: Includes 10 moisturizers, plus vitamins A, C, and E to nourish skin and help restore skin's moisture barrier
•ACTIVE INGREDIENT: Formulated with 1% hydrocortisone for maximum-strength itch relief without a prescription
•TRAVEL ESSENTIALS: The perfect addition to first aid kits, camping essentials and travel bags for anytime you need on-the-go relief
•FAST ACTING: Relieves itch in five minutes with 24-hour moisture that's gentle on skin, fragrance free, and dye free
•DOCTOR RECOMMENDED: Cortizone-10 is the No. 1 doctor-recommended OTC anti-itch brand* and is suitable for adults and children ages 2+ (*2024 IQVIA Study)

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$8.97

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Cortizone 10

Cortizone-10 Maximum Strength Soothing Aloe Itch Relief Cream, 1% Hydrocortisone, Fast-Acting, Anti-Itch Cream for Bug Bites, Rash, Eczema, Psoriasis, Poison Ivy, Oak, Sumac & More, 2 oz

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•INCLUDES: One (1) 2 oz. tube of Cortizone-10 Maximum Strength* Soothing Aloe Itch Relief Cream (*Among topical anti-itch OTCs)
•RELIEVES ITCH: Cortizone-10 helps relieve itch associated with minor skin irritations, inflammation, and rashes due to eczema, psoriasis, insect bites, seborrheic dermatitis, poison ivy, oak, sumac, and more
•ACTIVE INGREDIENT: Formulated with 1% hydrocortisone for maximum-strength itch relief without a prescription
•TRAVEL ESSENTIALS: The perfect addition to first aid kits, camping essentials and travel bags for anytime you need on-the-go relief
•FAST ACTING: Relieves itch in five minutes with a fragrance-free and dye-free formula
•DOCTOR RECOMMENDED: Cortizone-10 is the No. 1 doctor-recommended OTC anti-itch brand* and is suitable for adults and children ages 2+ (*2024 IQVIA Study)

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$8.49

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Benadryl

Benadryl Extra Strength Anti-Itch Relief Stick, Bug Bite Itch Relief, Diphenhydramine HCl Topical Analgesic & Zinc Acetate Skin Protectant, Great for Camping Essentials, 0.47 fl oz

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•0.47-fluid ounce travel sized stick of Benadryl Extra Strength Itch Relief Stick for kids ages 2 years and older with an anti-itch relief formula that provides fast relief from itching associated with most outdoor itches
•Mosquito bite stick starts working on contact to relieve the pain and itching associated with insect bites, minor burns, sunburn, minor skin irritations, minor cuts, scrapes, and rashes due to poison ivy, poison oak and poison sumac
•The extra strength anti-itch formula contains 2% diphenhydramine HCI, a topical analgesic pain reliever and 0.1% zinc acetate skin protectant. The anti-itch stick dries the oozing and weeping of poison ivy, poison oak, and poison sumac
•Extra strength bug bite itch relief stick for those ages two and up is easy-to-use and can be ap-plied directly to insect and mosquito bites. To use, hold straight down over affected area and press the tip repeatedly until liquid flows, then dab sparingly
•This extra strength topical analgesic stick is essential to keep on hand for your summer and outdoor activities Keep this convenient, travel sized itch stopping stick in your travel first aid kit, camping supplies, or hiking bag for relief on-the-go

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$4.09

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Sarna

Sarna Sensitive Anti-Itch Lotion, Steroid-Free, Fragrance-Free, Vegan, Hypoallergenic, National Eczema Association Accepted, 1% Pramoxine Hydrochloride, 12 oz

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•Give your skin the soothing care it needs with Sarna Sensitive Anti-Itch Lotion. This gentle moisturizing lotion is hypoallergenic and vegan.
•Relieve discomfort with 1% Pramoxine Hydrochloride for relief of pain and itch associated with minor cuts, minor burns, minor skin irritations and rashes due to poison ivy, poison oak, or poison sumac.
•Enriched with Aloe, Squalane, and Jojoba Oil, the lotion conditions and moisturizes the skin, ensuring hydration with each use, promoting overall skin health.
•Sarna Sensitive is vegan and free from steroids, fragrances, parabens, mineral oil, and hydroquinones.
•Accepted by the National Eczema Association.

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$11.83

$15.49

-24%

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Benadryl

Benadryl Extra Strength Itch Cooling Spray, Topical Analgesic Spray with Diphenhydramine HCI & Zinc Acetate Skin Protectant for Fast Relief from Insect Bites, Travel Size, 2 fl. oz

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•2-fluid ounce travel sized bottle of Benadryl Extra Strength Itch Cooling Spray for adults & children ages 2 & up to provide soothing relief from most outdoor itches
•Extra strength topical itch spray provides temporary cooling relief from most outdoor itches associated with insect bites, minor burns, sunburn, minor skin irritations, minor cuts, scrapes, & rashes due to poison ivy, poison oak & poison sumac
•Itch relieving formula contains 2% diphenhydramine hydrochloride, a topical analgesic pain reliever, & 0.1% zinc acetate skin protectant. The anti-itch topical rash relief spray dries the oozing & weeping of poison ivy, poison oak & poison sumac
•Intended for use by those ages 2 & up, anti-itch spray offers itch relief for kids & adults alike. Adults & children two years & older, apply the itch stopping topical analgesic spray to affected area no more than three to four times daily
•This extra strength topical insect spray is essential to keep on hand for your summer & out-door activities! Keep the convenient, travel size itch stopping spray in your travel first aid kit, camping supplies, or hiking bag for relief on-the-go

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$6.27

$8.06

-22%

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Gold Bond

Gold Bond Medicated Maximum Strength Pain & Itch Relief Cream, 1.75 oz., with Lidocaine

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•Includes one (1) 1.75-oz. tube of Gold Bond Medicated Maximum Strength Pain & Itch Relief Cream With Lidocaine
•Gold Bond Pain & Itch Cream with Lidocaine numbs away itching and pain due to minor skin irritations
•This pain and itch formula contains 4% lidocaine, the maximum strength available without a prescription*
•Gold Bond Lidocaine Cream starts working fast to relieve itching and pain associated with minor skin irritations
•This numbing cream is great for relieving pain and itch associated with sunburn, insect bites, and minor cuts, burns, and scrapes
•Create a TerraCycle account and start recycling your empty Gold Bond packaging

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$7.83

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Calagel

Tecnu Calagel Anti-Itch Gel, Maximum Strength Itch Relief for Rashes, Bug Bites, Stings and Minor Burn Relief, 6 oz

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•Quick, effective relief for insect bites, bug bites, sunburn and minor rashes
•Maximum strength pain relief and itch relief
•Wonderful for sunburn relief
•Goes on clear - no stains or pink residue
•Made with diphenhydramine HCl 2%

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$9.98

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A+Health

A+Health Extra Strength Itch Relief Gel, Diphenhydramine HCl 2% Topical Analgesic, Relives Itching and Pain for Bug Bites, Rashes, Poison Ivy, Oak Sumac, Made in USA, 4 Ounces

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•RELIEVE INSECT BITE AND RASH PAIN: Contains active ingredient Diphenhydramine HCl 2%
•STOP ITCHING IN ITS TRACKS: A+ Health Extra Strength Itch Relief Gel provides temporary relief from bug bites, scrapes, sunburns, minor cuts and skin irritation, and rashes caused by poison ivy, oak and sumac
•A BREAK FROM SCRATCHING: 2% diphenhydramine HCl gel cools itch sites, providing extra-strength relief by blocking histamines
•DON'T STOP THE FUN: Contains 4 fluid ounces of cooling solution, perfect for relieving itches, rashes and associated pains while you’re camping, hiking or enjoying outdoor activities
•FAST COOLING RELIEF: Easy-to-apply gel brings quick relief so you can get back to your active lifestyle. Extra Strength Itch Relief Gel is Made in the USA using ingredients originating from various countries.

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$4.35

$5.20

-16%

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