Top 10 Best suppository in 2026

Last Updated - 6/14/2026

🏆Best Choice

Fleet

Fleet Laxative Glycerin Suppositories for Adult Constipation, 50 Count, 3 Pack

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•Fleet Laxative Glycerin Suppositories provide fast, effective relief from occasional constipation and irregularity in 15 minutes to 1 hour
•Laxative glycerin suppository works with your body to help gently unblock your system by attracting water into the colon
•Fleet suppositories' easy to use, lubricated gentle glide tips are uniquely cone-shaped and formulated with soothing aloe for easier insertion
•Fleet Laxative Glycerin Suppositories are stimulant-free laxatives for constipation relief
•Fleet is the number one doctor-recommended brand of enemas* and suppositories** *ProVoice Data 2/1/22 to 1/31/23; **IQVIA Survey, 5/1/23 to 4/30/24 and TABS, L52W thru 5/19/24

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$11.84

$14.80

-20%

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Fleet

Fleet Laxative Glycerin Suppositories for Adult Constipation, Adult Laxative Jar Aloe vera, 50 Count

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•Fleet Laxative Glycerin Suppositories provide fast, effective relief from occasional constipation and irregularity in 15 minutes to 1 hour
•Laxative glycerin suppository works with your body to help gently unblock your system by attracting water into the colon
•Fleet suppositories' easy to use, lubricated gentle glide tips are uniquely cone-shaped and formulated with soothing aloe for easier insertion
•Fleet Laxative Glycerin Suppositories are stimulant-free laxatives for constipation relief
•Fleet is the number one doctor-recommended brand of enemas* and suppositories** *ProVoice Data 2/1/22 to 1/31/23; **IQVIA Survey, 5/1/23 to 4/30/24 and TABS, L52W thru 5/19/24
•Contains 1 jar of Fleet Laxatives, Laxative Glycerin Suppositories for Adult Constipation, 50 suppositories

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$4.29

$5.99

-28%

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Fleet

Fleet Liquid Glycerin Suppositories for Constipation Relief, Fast and Effective Stimulant-Free Laxative, 4 Bottles per Pack, 7.5 mL Each, Pack of 3

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•Fleet Liquid Glycerin Suppositories provide fast, effective relief from occasional constipation and irregularity in 15 minutes to 1 hour
•Liquid Glycerin Suppository may provide relief from GLP-1 related constipation, consult your doctor
•Easy-to-use liquid suppositories come with a mess-free suppository applicator and lubricated gentle glide tip for gentle constipation relief
•Fleet Liquid Glycerin Suppositories are stimulant-free laxatives for constipation relief
•Fleet is the number one doctor-recommended brand of enemas* and suppositories** *ProVoice Data 2/1/22 to 1/31/23; **IQVIA Survey, 5/1/23 to 4/30/24 and TABS, L52W thru 5/19/24

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$15.87

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Preparation H

Preparation H Hemorrhoid Suppositories For Itching And Discomfort Relief - 12 Count (Pack of 1)

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•One package of 12 Preparation H Hemorrhoid Suppositories
•Hemorrhoid treatment delivers pain and itch relief caused by internal hemorrhoids
•Formulated to help soothe irritation
•Preparation H suppositories help reduce swollen hemorrhoidal tissue
•Preparation H Medicated Wipes can be used before inserting Preparation H Hemorrhoid Suppositories
•Hemorrhoid relief from the number 1 doctor recommended brand for hemorrhoid treatment (1)
•Preparation H is the number 1 doctor recommended brand for hemorrhoid treatment

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$8.98

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Dulcolax

Dulcolax Stimulant Laxative Medicated Suppositories, Predictable & Effective Constipation Relief, Bisacodyl 10 mg, 28 Count, Stimulant Laxatives

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•Includes: One (1) 28-count box of Dulcolax medicated stimulant laxative suppositories
•Works fast: Dulcolax suppositories provide fast relief from constipation in as little as 15 to 60 minutes
•Targets the source: Suppositories deliver the active ingredient directly into the rectum for localized relief where it's needed
•Effective active ingredient: Dulcolax medicated laxative suppositories are made with 10 mg bisacodyl, which stimulates your gut muscles to move things out
•On-the-go relief: Pack these compact laxative suppositories in your travel essentials to help you get back to being regular when stress and overindulgence slow you down
•Doctor recommended: Dulcolax is the No. 1 doctor-recommended brand among OTC stimulant laxative brands
•Comfort-shaped: These laxative suppositories are made to comfortably insert and retain to give you the relief you need

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$18.71

$29.99

-38%

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Dulcolax

Dulcolax Stimulant Laxative Medicated Suppositories, Predictable & Effective Constipation Relief, Bisacodyl 10 mg, 4 Count

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•Includes: One (1) 4-count box of Dulcolax medicated stimulant laxative suppositories
•Works fast: Dulcolax suppositories provide fast relief from constipation in as little as 15 to 60 minutes
•Targets the source: Suppositories deliver the active ingredient directly into the rectum for localized relief where it's needed
•Effective active ingredient: Dulcolax medicated laxative suppositories are made with 10 mg bisacodyl, which stimulates your gut muscles to move things out
•On-the-go relief: Pack these compact laxative suppositories in your travel essentials to help you get back to being regular when stress and overindulgence slow you down
•Doctor recommended: Dulcolax is the No. 1 doctor-recommended brand among OTC stimulant laxative brands
•Comfort-shaped: These laxative suppositories are made to comfortably insert and retain to give you the relief you need

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$5.41

$6.99

-23%

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vH essentials

vH essentials Prebiotic PH Balanced Vaginal SuppositoriesBox, Original Version, 15 Count

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•One box of 15 vH essentials Prebiotic pH balanced vaginal Suppositories
•Feminine Hygiene prebiotic Suppository naturally protects against unwanted or unpleasant vaginal odor
•Ph balanced vaginal Suppository has prebiotic enriched formula
•Fructo-oligosaccharides and lactic acid help maintain balance, freshness and confidence
•Can be used regularly each day for a fresh and clean feeling

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$7.12

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AVEDANA

AVEDANA USP 2g Glycerin Laxatives Suppository – 100 Adult Size Laxative Suppositories for Men and Women – Fast and Gentle Relief Suppositories for Constipation – Comfortable Shape Adult Suppository

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•The Ideal Choice: Say goodbye to pain and discomfort with the Avedana constipation relief suppositories! Our special formula can bring fast and gentle relief that will restore your inner balance and make you feel better again.
•Fast and Effective: These laxative suppositories can help relieve discomfort within minutes from insertion. Our suppositories may help alleviate constipation symptoms and stimulate bowel movement in 15 minutes to one hour.
•Gentle Relief: The Avedana glycerin suppositories are an efficient and safe solution to relieve occasional constipation. They have a powerful laxative effect that delivers gentle and fast relief and a soothing effect. Customer Rated No. 1 for Colon
•Ergonomic Shape: We designed these suppositories for constipation with your health and safety in mind. That is why the Avedana suppositories, compared with other similar products on the market, have a unique shape for easy, painless insertion.
•How It Works: Our suppository laxative pack is formulated with special ingredients and 2g of glycerin per capsule for maximum benefits. Glycerin absorbs water and can help stimulate bowel movement, so make sure to drink plenty of water for efficient results.

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$9.99

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Amazon Basic Care

Amazon Basic Care Hemorrhoidal Suppositories, Relief from Burning, Itching and Discomfort of Hemorrhoids, 24 Count

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•ACTIVE INGREDIENTS: The active ingredients are cocoa butter 88.44 percent, protectant, and phenylephrine HCl 0.25 percent, vasoconstrictor, in each suppository; compare to active ingredients of Preparation H Hemorrhoidal Suppositories
•GOODBYE BURNING AND ITCHING: Amazon Basic Care Hemorrhoidal Suppositories help provide prompt, soothing relief from painful burning, itching and discomfort associated with hemorrhoids
•RELIEVES SWELLING: Fast-acting and shrinks swollen hemorrhoidal tissues; reduces internal swelling, soothes and protects
•PROTECTS TISSUE: Soothes and protects inflamed tissue and prevents further irritation
•NIGHTTIME: Also for nighttime relief; helps relieve itching, burning and discomfort of hemorrhoids; for your protection, each suppository is sealed in printed blister packaging with easy open wrapper

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$8.56

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AVEDANA

AVEDANA Bisacodyl Laxative Suppository | USP 10mg for Fast, Gentle Constipation Relief | Comfort-Shaped, Pack of 16 Suppositories

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•Optimal Solution: The Avedana bisacodyl suppositories have an efficient laxative formula that can help provide quick relief from occasional constipation. Our suppositories may help alleviate discomfort and pain so you can regain your vitality.
•Effective Formula: These suppositories for constipation contain a powerful active ingredient, bisacodyl 10mg USP, known for its amazing effect on constipation and discomfort by stimulating bowel movement in a natural way.
•Fast Relief: With the Avedana suppositories, you can wave goodbye to the uncomfortable feeling caused by constipation or irregularity. This formula provides constipation relief for adults as quickly as 15 minutes to an hour.
•Comfort-Shaped: Our laxatives for constipation are carefully shaped to ensure easy insertion without creating any discomfort or pain. They have a smooth surface and a comfortable shape that makes the insertion simply effortless and pain-free.
•What You Get: The Avedana constipation relief suppositories come in a convenient and affordable pack of 16 pieces. The package is compact and easy to carry, so you can intervene in time in case of an emergency anywhere you are.

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$9.99

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