Top 10 Best naproxen sodium pm in 2026

Last Updated - 6/27/2026

🏆Best Choice

Amazon Basic Care

Amazon Basic Care Acetaminophen PM Caplets, Pain Reliever Plus Nighttime Sleep Aid, Extra Strength, Helps Occasional Minor Aches, Pains and Headache Relief, 100 Count, Packaging may vary

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENTS: The active ingredients in Amazon Basic Care Acetaminophen PM are acetaminophen 500 mg, pain reliever, and diphenhydramine HCl 25 mg, nighttime sleep aid. Compare to Extra Strength Tylenol PM Caplets active ingredients
•LESS PAIN, MORE SLEEP: Minor aches & pains can interfere with restful sleep. Amazon Basic Care Acetaminophen PM has 500 mg acetaminophen, pain reliever, and 25 mg of diphenydramine hydrochloride, nighttime sleep aid, together in easy-to-swallow caplets
•USE: Amazon Basic Care Acetaminophen PM may be used as a pain reliever and nighttime sleep aid for adults and children 12 years and over. Child-resistant cap.
•EFFECTIVE SLEEP AID: For pain with sleeplessness. Relieve minor pain with extra-strength Amazon Basic Care Acetaminophen PM nighttime sleep aid medicine which is aspirin free and gluten free.
•NON-HABIT FORMING: Extra strength Amazon Basic Care Acetaminophen PM Caplets are non-habit forming when used correctly.

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$5.97

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Amazon Basic Care

Amazon Basic Care Naproxen Sodium Tablets, 200 Count (Pack of 1) (Packaging may vary)

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENT: This pain reliever and fever reducer contains naproxen sodium 220 mg, a nonsteroidal anti-inflammatory drug (NSAID); compare to the active ingredient in Aleve Caplets
•STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours so you can get through the day
•ACHES AND PAINS: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold; also temporarily reduces fever
•ALL DAY RELIEF: Amazon Basic Care Naproxen Sodium Tablets 220 mg is a pain reliever and fever reducer for adults and children age 12 years and over
•CAPSULE-SHAPED TABLETS: This 12 hour pain reliever and fever reducer comes in a capsule-shaped tablet; this product is gluten free

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$9.99

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Amazon Basic Care

Amazon Basic Care Ibuprofen PM, Ibuprofen 200 mg and Diphenhydramine Citrate 38 mg Tablets, Pain Reliever and Nighttime Sleep-Aid, 120 Count (Packaging may vary)

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENTS: This nighttime pain relief medicine contains ibuprofen 200 mg, a pain reliever (NSAID), and diphenhydramine citrate 38 mg, a nighttime sleep-aid; compare to Advil PM active ingredients
•NIGHTTIME SLEEP AID: Amazon Basic Care Ibuprofen PM contains a combination of a nighttime sleep-aid and a pain reliever (NSAID) that provides relief of occasional sleeplessness when associated with minor aches and painsPAIN RELIEF: Muscles, bones and joints are vulnerable targets for pain to attack; pain may begin with an injury or illness
•FOR ADULTS AND CHILDREN 12 YEARS AND OVER: Amazon Basic Care Ibuprofen PM tablets are used as a pain reliever (NSAID) and sleep aid for adults and children 12 years and over
•GLUTEN FREE: Amazon Basic Care Ibuprofen PM are coated caplets (capsule-shaped tablets) in a safety sealed bottle; this product is gluten free
•Product may be manufactured in India or U.S.

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$11.99

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HealthA2Z

HealthA2Z® Extra Strength Pain Relief PM| Acetaminophen 500mg | Diphenhydramine 25mg | Pain Reliever & Nighttime Sleep Aid | (365 Count (Pack of 1))

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•500 mg Acetaminophen, a proven pain reliever, helps relieve muscle, joint, headache, and arthritis pain quickly.
•25 mg Diphenhydramine, a gentle, non-habit-forming sleep aid, helps you fall asleep and stay asleep while also relieving fever and minor aches and pain with the help of Acetaminophen.
•It contains NO Aspirin
•Adults and children 12 years and over: take 2 caplets at bedtime. Do not take more than 2 caplets of this product per 24 hours/ Children under 12 years do not use.
•No gluten added product

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$14.95

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Aleve

Aleve PM Sleep Aid Plus Pain Reliever Caplets, Naproxen Sodium & Diphenhydramine HCl, Nighttime, 120 Count

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•Say hello to a good night’s sleep with pain relief
•Aleve PM provides relief of occasional sleeplessness when associated with minor aches and pains
•Helps you fall asleep and stay asleep
•Sleep Aid plus 12 hour pain relieving strength of Aleve
•Contains diphenhydramine hydrochloride (nighttime sleep-aid) and naproxen sodium (pain reliever)
•Use as directed

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$19.13

$24.99

-23%

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GoodSense

GoodSense Naproxen Sodium Tablets, 220 mg, 400 Count

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•ACTIVE INGREDIENT: The active ingredient in GoodSense Naproxen Sodium Tablets, 220 mg is Naproxen Sodium; Compare to Aleve Caplets active ingredient
•STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours
•PAIN RELIEVER: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold; Also temporarily reduces fever
•NAPROXEN SODIUM: A nonsteroidal anti-inflammatory drug (NSAID) used as a pain reliever/fever reducer
•FOR ADULTS AND CHILDREN 12 YEARS AND OLDER: Children under 12 years: ask a doctor

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$17.47

$18.99

-8%

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Amazon Basic Care

Amazon Basic Care Back and Muscle Pain, 220 mg, 12-Hour Pain Relief, Naproxen Sodium Tablets, Pain Reliever and Fever Reducer, 90 Count

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•ACTIVE INGREDIENT: Amazon Basic Care Back and Muscle Pain contains the active ingredient naproxen sodium 220, a nonsteroidal anti-inflammatory drug (NSAID) and pain reliever/fever reducer. Compare to the active ingredient in Aleve Back and Muscle Pain.
•BACK and MUSCLE: Count on up to 12 hours of relief with one dose of Amazon Basic Care Back and Muscle Pain Naproxen Sodium Tablets, 220 mg, a pain reliever and fever reducer for temporary relief of minor back and muscle aches and pains.
•MINOR ACHES and PAINS: Amazon Basic Care Back and Muscle Pain Naproxen Sodium Tablets, 220 mg also alleviates: backache, muscular aches, minor pain of arthritis, menstrual cramps, headache, toothache, the common cold and temporarily reduces fever.
•12 HOURS: A pain reliever and fever reducer with the strength to last 12 hours means stopping less often to take more doses.
•ADULTS and ADOLESCENTS: This product contains naproxen sodium 220 mg, a pain reliever and fever reducer for use in adults and children age 12 years and older.

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$8.75

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HealthCareAisle

HealthCareAisle Naproxen Sodium, 220 mg - 200 caplets - Pain Reliever and Fever Reducer, Up to 12 Hours of Relief

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•Naproxen Sodium caplets temporarily relieve minor aches and pains due to: minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache, the common cold; also temporarily reduces fever
•Comparable to the national brand: Has the same active ingredient as Aleve Caplets*
•Effective pain and fever relief for up to 12 hours
•See package label for warnings, directions and other important information; use only as directed
•HSA or FSA Eligible

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$9.58

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Amazon Basic Care

Amazon Basic Care Headache Pain Relief Naproxen Sodium Tablets 220 mg, Also Relieves Arthritis, Muscular Aches, Backache, Menstrual Cramps and Toothache, 90 Count

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•ACTIVE INGREDIENT: The active ingredient in Amazon Basic Care Naproxen Sodium Tablets 220 mg, Headache Relief, is naproxen sodium 220 mg, a nonsteroidal anti-inflammatory drug (NSAID). Compare to Aleve Headache Pain Tablets active ingredient.
•HEADACHE PAIN RELIEF and relief for ailments like minor pain of arthritis, backache, the common cold, muscular aches, menstrual cramps and toothache. Amazon Basic Care Naproxen Sodium Tablets 220 mg help you to keep going.
•LASTS 12 HOURS: Amazon Basic Care Naproxen Sodium Tablets 220 mg have the strength to last 12 hours with just one dose
•USE: Amazon Basic Care Naproxen Sodium Tablets 220 mg may be used as a pain reliever and fever reducer for adults and children 12 years and over
•GLUTEN FREE: Amazon Basic Care Naproxen Sodium Tablets 220 mg are a gluten free option for temporary relief of minor aches and pains as well as fever reduction

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Amazon Basic Care

Amazon Basic Care All Night Pain Relief PM, Naproxen Sodium, 220 mg/Diphenhydramine Hydrochloride, 25 mg Tablets, Pain Reliever/Nighttime Sleep-Aid, 160 Count

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•ACTIVE INGREDIENTS in this product are naproxen sodium 220 mg, a pain reliever, and diphenhydramine hydrochloride 25 mg, a nighttime sleep-aid. Compare to Aleve pm active ingredients.
•NAPROXEN SODIUM PM from Amazon Basic Care pairs diphenhydramine HCl 25 mg, a nighttime sleep-aid, with the 12-hour pain relief of naproxen sodium 220 mg to help you fall asleep and stay asleep.
•THE ACHES AND PAINS of the day can follow you into nighttime and prevent a good night's rest. The active ingredient naproxen sodium 220 mg is a NSAID (nonsteroidal anti-inflammatory drug) pain reliever.
•FALLING ASLEEP AND STAYING ASLEEP can be tough when aches and pains plague you in the nighttime. The active ingredient diphenhydramine hydrochloride 25 mg is a nighttime sleep-aid. Get the rest you need tonight for a better tomorrow.
•Amazon Basic Care NAPROXEN SODIUM PM CAPLETS: This nighttime product is for occasional sleeplessness associated with minor aches and pain for adults and children 12 years and over. capsule-shaped tablets

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$21.98

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