Top 10 Best sinex in 2026

Last Updated - 6/16/2026

🏆Best Choice

Amazon Basic Care

Amazon Basic Care Maximum Strength Mucus DM, Expectorant and Cough Suppressant Extended-Release Tablets, 42 Count

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENTS: Amazon Basic Care Maximum Strength Mucus Relief DM tablets contain dextromethorphan HBr and guaifenesin; compare to the active ingredients in Maximum Strength Mucinex DM
•MAXIMUM STRENGTH: 1200 mg of guaifenesin and 60 mg of dextromethorphan HBr team up to take on your toughest cold
•EFFECTIVE: Amazon Basic Care Maximum Strength Mucus-DM clears your chest congestion and eases the intensity of coughing
•COUGH SUPPRESSANT: This 12-hour cough medicine contains dextromethorphan HBr for cough relief; it relieves the impulse to cough to help you get to sleep
•COUGH EXPECTORANT: Contains guaifenesin to help loosen phlegm so you can cough up that bothersome mucus; makes coughs more productive

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$16.79

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Mucinex

Mucinex 12 Hour Maximum Strength Extended-Release Tablets, 42 Tablets

9.6

ChoiceComparer.com Score

9.6

/ 10

Outstanding

Main highlights

•Maximum Strength Mucinex 12hr extended-release tablets with 1200 mg guaifenesin provide chest congestion relief
•USAGE: Use as directed; For ages 12+ years

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$28.37

$29.99

-5%

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Mucinex

Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count

9.4

ChoiceComparer.com Score

9.4

/ 10

Outstanding

Main highlights

•PAIN RELIEF: Acetaminophen helps reduce fever and helps relieve body aches and headache associated with cold and flu
•EXCESS MUCUS RELIEF: The expectorant, Guaifenesin, provides effective excess mucus relief by thinning and loosening bothersome mucus in your chest, helping to clear chest congestion
•COLD MEDICINE: Mucinex Rapid Clear Pain, Headache, & Mucus Congestion is a trusted cold medicine for adults, offering comprehensive relief from cold and flu symptoms including fever, body pain, sore throat, headache, and excess mucus
•HEADACHE RELIEF: Helps relieve headaches including those associated with cold and flu
•EXPECTORANT: Contains Guaifenesin, an expectorant that aids in thinning and loosening mucus for more productive coughs and chest congestion relief
•RAPID RELEASE CAPLETS: Mucinex Rapid Clear caplets start working fast
•MAXIMUM STRENGTH & NON-DROWSY: With Mucinex Rapid Clear, it's not "power through with a pounding headache" season—It's comeback season

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$13.99

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Mucinex

Mucinex Fast-Max Cold and Flu & Nightshift Medicine for Adults, Over-The-Counter Medication Combo Pack for Sore Throat Relief, Decongestant, Cough & Cold Medicine (2 x 6 Fl Oz)

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•COUGH COLD AND FLU MEDICINES FOR ADULTS: This combo pack of Maximum Strength Mucinex Fast-Max Cold & Flu and Nightshift Severe Cold & Flu provides powerful multi-symptom cold and flu relief for your worst cold and flu symptoms
•SORE THROAT RELIEF: Both liquids contain Acetaminophen, which helps reduce fever and relieves sore throat, headache, and body pain
•COUGH MEDICINE FOR ADULTS: Both liquids contain Dextromethorphan HBr, which helps suppress and quiet cough
•CHEST CONGESTION RELIEF: Daytime liquid contains Guaifenesin, an expectorant, which helps relieve chest congestion and thins and loosens mucus
•NASAL DECONGESTANT: Both liquids contain Phenylephrine HCl, a nasal decongestant, which helps relieve stuffy nose, sinus pressure, & nasal congestion
•NIGHTTIME COLD AND FLU MEDICINE FOR ADULTS: Nighttime liquid contains Triprolidine HCl, an antihistamine, which helps relieve runny nose & sneezing
•USAGE: Use as directed; For ages 12+ years

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$21.30

$22.49

-5%

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Mucinex

Mucinex Fast-Max Severe Congestion & Cough Medicine, Maximum Strength Symptom Relief, Over-The-Counter Medication, Cold Medicine, Cough Suppressant, Expectorant, Nasal Decongestant, 6 Fl Oz

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•COUGH COLD AND FLU MEDICINES FOR ADULTS: Maximum Strength Mucinex Fast Max Severe Congestion & Cough provides powerful multi-symptom relief for your worst symptoms including cough, chest congestion, and nasal congestion
•EXPECTORANTS AND DECONGESTANTS FOR ADULTS : Maximum Strength Mucinex Fast-Max Severe Congestion & Cough has a triple action formula that relieves nasal & chest congestion, controls cough & thins & loosens mucus to help clear lungs of excess mucus
•POWERFUL COUGH & COLD ACTIVE INGREDIENTS: Contains Dextromethorphan HBr - Cough suppressant; Guaifenesin - Expectorant; Phenylephrine HCI - Nasal decongestant
•USAGE: Use as directed; For ages 12+ years

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$11.72

$17.98

-35%

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Mucinex

Mucinex Fast-Max Maximum Strength Day & Night Cold and Flu Medicine for Adults, Powerful Over-The-Counter Medication for Cold & Flu Symptoms, Fast Dissolving Liquid Gels, 24 Count

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•COLD AND FLU MEDICINE: Mucinex Fast-Max Daytime Cold & Flu & Nighttime Cold & Flu liquid gels give powerful relief for headache, sore throat, body pain, fever, cough, runny nose and more
•PAIN & FEVER RELIEF: Acetaminophen helps reduce fever and relieve pain like headache, body aches, sore throat including those associated with cold & flu
•COUGH SUPPRESSANT: Contains Dextromethorpan HBr which helps suppress the urge to cough during the day and at night to help you get to sleep
•RUNNY NOSE RELIEF: Doxylamine succinate helps relieve runny nose, sneezing, itchy throat, & itchy/watery eyes (nighttime liquid gels only)
•NOTHING WORKS FASTER**: Fast dissolving liquid gels for powerful multi-symptom cold and flu relief day and night
•FLU MEDICINE FOR ADULTS: Mucinex Fast-Max Daytime Cold & Flu & Nighttime Cold & Flu liquid gels provides multi-symptom relief for your worst symptoms day and night
•#1 TRUSTED COLD & COUGH BRAND: Mucinex is the #1 cough and cold brand doctors trust*
•**Among oral OTC cold & flu liquid gels

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$18.47

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Mucinex

Mucinex Chest Congestion, Expectorant 12 Hour Extended Release Tablets, 20ct, 600mg Guaifenesin with Extended Relief of Chest Congestion Caused by Excess Mucus. Thins and Loosens Mucus

8.7

ChoiceComparer.com Score

8.7

/ 10

Good

Main highlights

•EXCESS MUCUS RELIEF: Mucinex 12hr extended-release tablets pack a powerful punch with 600 mg guaifenesin expectorant, providing you with long-lasting chest congestion relief
•AIDS EXCESS MUCUS REMOVAL: Mucinex SE lasts up to 12 hours, provides chest congestion relief and makes coughs more productive
•EXPECTORANTS FOR ADULTS: Mucinex helps clear lungs by thinning & loosening mucus; Say goodbye to excess mucus, say hello to chest congestion relief
•EXTENDED RELEASE GUAIFENESIN: Experience long-lasting excess mucus relief with Mucinex's 12hr extended-release 600mg guaifenesin tablets; our original bi-layer tablets have both immediate & extended release
•COLD AND FLU MEDICINE FOR ADULTS: For powerful cough, cold, and flu multi-symptom relief, check out our range of Mucinex Fast-Max cold and flu medicines; Beat cold and flu symptoms with confidence
•USAGE: Use as directed; For ages 12+ years
•QUALITY YOU CAN TRUST: Mucinex uses carbomer that is manufactured without the use of benzene

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$12.48

$13.99

-11%

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Mucinex

Mucinex 12 Hour Extended Release Tablets, 600 mg Guaifenesin Relieves Chest Congestion Caused by Excess Mucus, #1 Doctor Recommended OTC Expectorant, Blue, 40 Count

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•Helps relieve chest congestion: Contains 600 mg guaifenesin expectorant in extended-release tablets
•Long-lasting formula: Provides chest congestion relief for up to 12 hours
•Helps thin and loosen mucus: May help make coughs more productive
•Bi-layer tablet design: Features both immediate and extended release of active ingredient
•Trusted brand: Mucinex is a leading over-the-counter expectorant recommended by healthcare professionals
•Also available: Mucinex offers a range of multi-symptom cold and flu relief products
•May be FSA/HSA eligible: Check with your benefits administrator regarding coverage of expenses
•Quality ingredients: Manufactured without the use of benzene

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$15.29

$25.49

-40%

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