Top 10 Best antibiotic cream for skin infection in 2026

Last Updated - 6/27/2026

🏆Best Choice

Neosporin

Neosporin Original First Aid Triple Antibiotic Ointment, Bacitracin Zinc & Neomycin Sulfate Infection Protection, Wound Care Treatment & Scar Appearance Minimizer for Minor Cuts, Scrapes & Burns, 1 oz

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•Triple antibiotic protection: Formula combines neomycin sulfate, bacitracin zinc, and polymyxin B antibiotic ingredients for 24-hour infection protection in minor cuts, scrapes, and burns; HeliDerm Technology nourishes skin for healthier healing
•Gentle non-greasy application: Topical antibiotic ointment absorbs quickly with no excessive oily residue for comfortable wear; versatile antibiotic action soothes, heals, and protects multiple minor wounds for long-lasting infection protection
•Scar minimizer: HeliDerm Technology provides a nourishing environment that lock in moisture to support natural skin repair and reduce scar appearance after healing; from the #1 doctor-recommended brand for reliable topical antibiotic ointment results
•Multi-use wound care: Ideal for minor cuts, scrapes, and burns; apply a small-sized dab one to three times daily and cover with a BAND-AID Brand sterile bandage for extra protection, supporting continuous 24-hour infection protection and healing
•Portable convenience: Neosporin Original 1 oz tube is compact for home, travel, and first aid kits; trusted triple antibiotic ointment formula by Kenvue delivers dependable infection protection wherever and whenever you need it

View offer on:

$8.48

$11.78

-28%

Check Price

Globe

Globe Triple Antibiotic Ointment 1.0 oz (4 Pack), First Aid Ointment for Minor Scrapes, Cuts, and Burns to Help Prevent Infection, Compare to The Active Ingredients of The Leading Brand.

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•INFECTION PROTECTION: Globe Triple Antibiotic Ointment helps to soothe painful cuts, scrapes, and burns while preventing infection. 100% Infection Protection!! Healing Ointment
•FIRST AID KIT: Globe Triple Action Antibiotic ointment is a must have product in your first aid kit. Its a skin care treatment for minor cuts, scrapes, and burns. Frist class First Aid Treatment for Minor Cuts, Scars, Eczema, Scraps, and Burns. Perfect Healing Ointment for your First Aid Cabinet.
•VALUE PACK: Globe Triple Antibiotic Ointment Value Pack comes with 4 single 1 oz tubes. The Globe Triple Antibiotic Value pack includes 4 individual tubes (1 oz each- a total of 4 oz) to take with you anywhere.
•EASY TO TAKE WITH YOU: Keep Globes Triple Antibiotic Ointment 4 tubes Value Pack in your medicine closet, car, camping bag, purse, kitchen drawer, kid's backpack, and even your travel carryon luggage. The convenience of the tube size can go with you anywhere.
•WHATS INSIDE: Globe Triple Antibiotic Ointment contains the same active antibiotic ingredients as the leading name brand: neomycin, bacitracin and polymyxin. It provides 24-hour protection against infection in minor cuts scrapes and burns.
•QUALITY: Manufactured in accordance with the highest pharmaceutical manufacturing processes and contains a NDC for 100% confidence. US FDA audited manufacturing facilities. Trifecta Pharmaceuticals USA is a family business based in sunny Fort Lauderdale, Florida USA.

View offer on:

$7.32

$12.99

-44%

Check Price

Polysporin

Polysporin First Aid Topical Antibiotic Skin Ointment with Bacitracin Zinc & Polymyxin B Sulfate, for Infection Protection & Wound Care, Neomycin-Free, Travel Size, 0.5 oz

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•0.5-ounce tube of Polysporin First Aid Antibiotic Skin Ointment for effective wound care of minor cuts, scrapes and burns
•This topical antibiotic ointment helps provide effective infection prevention for minor wounds
•From the #1 dermatologist-recommended first aid ointment for infection prevention, the unique neomycin-free formula combines the antibiotic power of the infection-fighting ingredients bacitracin zinc (500 units/gram) with polymyxin B sulfate (10,000 units/gram)
•To use, apply a small amount of this product to affected area 1 to 3 times daily, then cover with a sterile bandage.Available in a convenient TSA-friendly travel size for on-the-go wound care, this antibiotic ointment also makes a great addition to a home first aid kit
•Available in a convenient TSA-friendly travel size for on-the-go wound care, this antibiotic ointment also makes a great addition to a home first aid kit

View offer on:

$5.98

$8.35

-28%

Check Price

Aquaphor

Aquaphor Healing Ointment, Advanced Therapy Skin Protectant, Multi-Purpose Healing Ointment and Body Moisturizer, For Dry, Cracked Skin, Minor Cuts and Burns, 14 Oz Jar

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•ONE ESSENTIAL SOLUTION: Aquaphor is one essential solution for many skin care needs; use on dry, cracked skin, as a lip moisturizer, facial moisturizer, hydrating mask, minor wound care and much more
•FOR DRY, COMPROMISED SKIN: This Aquaphor Healing Ointment is designed specifically for dry, compromised skin and clinically proven to restore smooth, healthy skin
•CONVENIENT REPLACEMENT: Use Aquaphor Healing Ointment as a replacement for a foot cream or hand cream to help heal dry cracked hands, cuticles and feet
•IDEAL FOR HEALING: Different from a body lotion or cream, this ointment is water-free, and soothes skin while creating a protective barrier that allows for the flow of oxygen to create an ideal healing environment
•INCLUDES: one (1) 14 ounce jar of Aquaphor Healing Ointment Advanced Therapy Skin Protectant
•AWARD WINNING: Allure Best of Beauty 2023 Winner

View offer on:

$18.07

$19.99

-10%

Check Price

Bactine

Bactine MAX Antibiotic + Pain Relieving Ointment - Antibiotic Ointment with Lidocaine - Pain + Itch Relief for Minor Cuts & Scrapes & Burns - Lidocaine Numbing Cream - 0.5oz

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•MAX RELIEF FOR PAIN & ITCH: Bactine MAX is an all-in-one antibiotic ointment that relieves pain & kills germs from minor cuts, scrapes, burns & bug bites
•ANTIBIOTIC OINTMENT: 24 hour infection protection. Our first aid healing ointment is made with Bacitracin for killing germs fast to keep you protected
•NO-STING & NO WORRIES: Formulated with 4% lidocaine, the maximum amount allowed for OTC topical anesthetic. Unlike hydrogen peroxide, his antibiotic cream treats minor wounds, bug bites, and burns without a painful, harsh sting
•FIRST AID KIT MUST HAVE: Accidents happen, be prepared. Keep your first aid supplies stocked with Bactine MAX. Whether it’s a scraped knee, blistered heel or itchy bug bite, this anti-itch, pain relief first aid ointment provides cooling relief where you need it most
•TRUSTED FOR OVER 70 YEARS: With a legacy spanning over 70 years, Bactine has been the go-to choice for families seeking the best first aid available. Safe for adults and children 2 years old plus

View offer on:

$4.97

Check Price

Thera Care

Thera Care Triple Antibiotic Ointment | First Aid | Infection Prevention and Protection | 1.0 oz | Topical Wound Care for Minor Scrapes and Cuts

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•LONG-LASTING PROTECTION —Antibiotic ointment aids in treating minor cuts, scrapes and burns
•EASY AND EFFECTIVE — Clean affected area, apply a small amount of ointment to the affected area one to three times daily; cover with adhesive bandage.
•BACITRACIN ZINC — Helps prevent infection and helps minimize the appearance of scars
•SUPPORT AND INSTRUCTION — Follow the detailed use instructions, as well as the warnings and cautions, before use. Use only as directed, instructions are easy to follow and use
•Compare to Neosporin Antibiotic Ointment active ingredients
•1.0 oz. (28.3 g) tube
•Safety warning: For external use only. Do not use: if you are allergic to any of the ingredients, in the eyes, over large areas of the body
•Always read detailed instructions before use

View offer on:

$3.99

Check Price

Neosporin

Neosporin + Maximum-Strength Pain Relief Dual Action Cream, First Aid Topical Antibiotic and Analgesic Cream for Wound Care of Minor Cuts, Scrapes and Burns, Polymyxin B & Pramoxine HCl, 1 oz

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•Antibiotic cream: Neomycin sulfate and polymyxin B sulfate deliver dual antibiotic action with up to 24-hour protection in a first-aid cream, helping prevent infection from minor cuts, scrapes, and burns when used as directed
•Pain relief analgesic: Pramoxine HCl provides maximum-strength pain relief as an external analgesic in a non-greasy, stain-free, no-sting formula that soothes discomfort from minor scrapes, burns, and cuts
•First-aid cream convenience: Includes one 1 oz tube (sold individually) for easy portability in backpacks, purses, and travel kits; apply one to three times daily after cleansing the affected area for straightforward, on-the-go wound care
•Sting-free formula: Fragrance-free, Neosporin + Pain Relief Dual Action Antibiotic Cream applies to skin easily, absorbs quickly without residue, and won't stain fabrics, supporting comfortable daily wound care for minor cuts, scrapes, and burns
•Complete wound care: Dual-action antibiotic cream and external analgesic help prevent infection for 24-hour protection and soothe pain in minor wounds; pair with a BAND-AID Brand sterile bandage after application for best results in first-aid kits

View offer on:

$9.88

$12.39

-20%

Check Price

MED PRIDE

MED PRIDE Bacitracin with Zinc Ointment Antibiotic Bacitracin for Infection Prevention and Skin Relief, 1 Oz Tube

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•SOOTHING PROPERTIES: Experience the soothing properties of bacitracin zinc ointment, a versatile solution for various skin irritations. Not just a treatment, bacitracin zinc ointment usp also prevents further issues, offering relief from chaffing, dermatitis, eczema, and itchy or dry skin.
•FIRST-AID ESSENTIAL: Understand the importance of having a first-aid essential like bacitracin ointment at home. This zinc cream for wounds is not just about treating existing conditions, but also about preventing potential infections from common household incidents.
•ANTIBIOTIC CREAM: Trust in our antibiotic cream to inhibit bacterial growth that could lead to infections. Our bacitracin antibiotic ointment is not just about treating the symptoms, but also about addressing the root cause.
•PARENTAL BENEFITS: Explore the benefits of our zinc cream for new parents, forming a water-resistant coating that works exceptionally well with irritated or dry skin. More than just a rash cream for women, it promotes faster recuperation and is ideal for soothing diaper rash.
•ENHANCED RESULTS: See improved results with our skin ointments, combining the Bacitracin component with Zinc for enhanced natural infection resistance and tissue repair processes. Our contact dermatitis treatment, with the added benefit of Zinc, provides a comprehensive solution for minor skin irritations and infections.

View offer on:

$3.97

Check Price

Amazon Basic Care

Amazon Basic Care First Aid Antibiotic Ointment, 2 ounce (Pack of 1)

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•ACTIVE INGREDIENTS: This Amazon Basic Care triple antibiotic ointment contains bacitracin from bacitracin zinc, neomycin sulfate and polymyxin B sulfate, which are first aid antibiotics and compare to the active ingredients in Neosporin
•LONG-LASTING INFECTION PROTECTION: Amazon Basic Care First Aid Antibiotic Ointment provides long-lasting, 24-hour infection protection for minor wounds
•HEALING CARE: Enhanced with vitamin E and cocoa butter to promote healing, resulting in healthy looking skin
•ORIGINAL STRENGTH: Triple antibiotic ointment helps to prevent infection in minor cuts, scrapes and burns
•HOW TO TREAT MINOR CUTS, SCRAPES AND BURNS: Clean the affected area and apply a small amount of Amazon Basic Care First Aid Triple Antibiotic Ointment on the area 1 to 3 times daily; may be covered with a sterile bandage

View offer on:

$5.17

$6.28

-18%

Check Price

terrasil

terrasil Wound Care 3X - Wound Healing Ointment, Infection Protection for Bed Sores, Pressure Sores, Blisters, Cuts, Burns & First Aid. Dermatologist-Tested, Hypoallergenic Approved (.5oz)

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•POWERFUL, EFFECTIVE PROTECTION & HEALING: Terrasil Wound Care is uniquely formulated to provide a powerful barrier against infection, killing 99.99% of bacteria. Soothing formula covers and protects damaged skin and supports faster healing of wounds, ulcers and sores.
•FAST RELIEF & SOOTHING OINTMENT: Calms inflammation and redness, minimizes risk of scarring, and reduces itching and irritation. Ideal care and relief for bed sores, leg sores, ulcers, burns, cuts, scrapes and wounds. Applies easily for soothing relief without the stinging found in other products. For use on body, neck, arms, hands, backside, legs, and feet. First aid kit must have.
•UNIQUE PATENTED TECHNOLOGY: Only Terrasil Wound Care contains Activated Minerals, backed by over 20 years of research & development, which together with select ingredients, effectively treats, protects and supports skin healing.
•DERMATOLOGIST TESTED, NATURAL, & SAFE: Provides therapeutic benefits with natural ingredients, including Jojoba Oil & Calendula, to moisturize damaged skin with soothing relief from itching, burning and soreness. Terrasil is paraben-free, alcohol-free, dye-free, fragrance-free, Dermatologist tested & Hypoallergenic approved, for even the most sensitive skin.
•EXCEPTIONAL QUALITY FOR POWERFUL RESULTS: Terrasil is formulated with the finest ingredients and made in the USA to the highest quality manufacturing standards. FSA & HSA eligible.

View offer on:

$19.95

Check Price

📊

📈 How we rank

With our cutting-edge technology, we examine thousands of products and retailers, assessing reviews, ratings, trends, and sales rankings to identify what matters most to users like you.

Our team evaluates this data alongside genuine user feedback, merging AI analysis with human insights to provide you with real-time, highly-rated recommendations that empower your decision-making with clarity and confidence.