Top 10 Best antibiotic cream with pain relief in 2026

Last Updated - 6/26/2026

🏆Best Choice

Neosporin

Neosporin Original First Aid Triple Antibiotic Ointment, Bacitracin Zinc & Neomycin Sulfate Infection Protection, Wound Care Treatment & Scar Appearance Minimizer for Minor Cuts, Scrapes & Burns, 1 oz

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•Triple antibiotic protection: Formula combines neomycin sulfate, bacitracin zinc, and polymyxin B antibiotic ingredients for 24-hour infection protection in minor cuts, scrapes, and burns; HeliDerm Technology nourishes skin for healthier healing
•Gentle non-greasy application: Topical antibiotic ointment absorbs quickly with no excessive oily residue for comfortable wear; versatile antibiotic action soothes, heals, and protects multiple minor wounds for long-lasting infection protection
•Scar minimizer: HeliDerm Technology provides a nourishing environment that lock in moisture to support natural skin repair and reduce scar appearance after healing; from the #1 doctor-recommended brand for reliable topical antibiotic ointment results
•Multi-use wound care: Ideal for minor cuts, scrapes, and burns; apply a small-sized dab one to three times daily and cover with a BAND-AID Brand sterile bandage for extra protection, supporting continuous 24-hour infection protection and healing
•Portable convenience: Neosporin Original 1 oz tube is compact for home, travel, and first aid kits; trusted triple antibiotic ointment formula by Kenvue delivers dependable infection protection wherever and whenever you need it

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$8.48

$11.78

-28%

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Bactine

Bactine MAX Antibiotic + Pain Relieving Ointment - Antibiotic Ointment with Lidocaine - Pain + Itch Relief for Minor Cuts & Scrapes & Burns - Lidocaine Numbing Cream - 0.5oz

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•MAX RELIEF FOR PAIN & ITCH: Bactine MAX is an all-in-one antibiotic ointment that relieves pain & kills germs from minor cuts, scrapes, burns & bug bites
•ANTIBIOTIC OINTMENT: 24 hour infection protection. Our first aid healing ointment is made with Bacitracin for killing germs fast to keep you protected
•NO-STING & NO WORRIES: Formulated with 4% lidocaine, the maximum amount allowed for OTC topical anesthetic. Unlike hydrogen peroxide, his antibiotic cream treats minor wounds, bug bites, and burns without a painful, harsh sting
•FIRST AID KIT MUST HAVE: Accidents happen, be prepared. Keep your first aid supplies stocked with Bactine MAX. Whether it’s a scraped knee, blistered heel or itchy bug bite, this anti-itch, pain relief first aid ointment provides cooling relief where you need it most
•TRUSTED FOR OVER 70 YEARS: With a legacy spanning over 70 years, Bactine has been the go-to choice for families seeking the best first aid available. Safe for adults and children 2 years old plus

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$4.97

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Neosporin

Neosporin + Maximum-Strength Pain Relief Dual Action Cream, First Aid Topical Antibiotic and Analgesic Cream for Wound Care of Minor Cuts, Scrapes and Burns, Polymyxin B & Pramoxine HCl, 1 oz

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•Antibiotic cream: Neomycin sulfate and polymyxin B sulfate deliver dual antibiotic action with up to 24-hour protection in a first-aid cream, helping prevent infection from minor cuts, scrapes, and burns when used as directed
•Pain relief analgesic: Pramoxine HCl provides maximum-strength pain relief as an external analgesic in a non-greasy, stain-free, no-sting formula that soothes discomfort from minor scrapes, burns, and cuts
•First-aid cream convenience: Includes one 1 oz tube (sold individually) for easy portability in backpacks, purses, and travel kits; apply one to three times daily after cleansing the affected area for straightforward, on-the-go wound care
•Sting-free formula: Fragrance-free, Neosporin + Pain Relief Dual Action Antibiotic Cream applies to skin easily, absorbs quickly without residue, and won't stain fabrics, supporting comfortable daily wound care for minor cuts, scrapes, and burns
•Complete wound care: Dual-action antibiotic cream and external analgesic help prevent infection for 24-hour protection and soothe pain in minor wounds; pair with a BAND-AID Brand sterile bandage after application for best results in first-aid kits

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$9.88

$12.39

-20%

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CareAll

CareAll Triple Antibiotic Ointment + Pain Relief 1.0 oz (4 Pack), Dual Action First Aid for Minor Scrapes, Cuts, and Burns to Help Prevent Infection While Providing Maximum Strength Pain Relief.

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•FIRST AID PLUS PAIN RELIEF Triple Antibiotic Ointment for the prevention of infections in minor cuts, scrapes and burns while providing maximum strength pain relief.
•FORMULATED with you in mind. CareALL Triple Antibiotic plus pain relief ingredients are phthalate-free, paraben-free, dye-free, and fragrance-free.
•ACTIVE INGREDIENTS Compare to the Active Ingredients to Leading Brand. Active Ingredients (in each gram): Bacitracin Zinc 500 Units, Neomycin Sulfate 3.5mg, Polymyxin B Sulfate 10,000 units, Pramoxine HCI 10mg
•TAMPER PROOF each 1oz Tube has a tamper evident foil safety seal for your safety.
•FDA REGISTERED with NDC# (National Drug Code Number) printed on packaging with LOT # and Expiration Date. For External Use Only.

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$9.99

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Globe Pharmacy

(4 Pack) Globe Dual Action First Aid Antibiotic Cream + Pain Relief, Neomycin, Polymyxin B, Pramoxine HCl, Soothes Painful Cuts, Burns and Scrapes, 24 Hour Infection Protection

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•FIRST AID ANTIBIOTIC + PAIN RELIEF CREAM: Globe First Aid Cream with Pain Relief provides a maximum strength topical solution for minor cuts, burns, and scrapes. This powerful first aid cream protect against infections and soothe painful wounds for up to 24 hours.
•ACTIVE INGREDIENTS FOR INFECTION CARE: Formulated with Neomycin, Polymyxin B, and Pramoxine HCl, this first aid antibiotic cream offers strong, fast relief. It provides powerful protection against skin infections while offering pain relief, making it an essential addition to any first aid or medical kit for emergency care.
•TRAVEL-SIZE CONVENIENCE: Globe First Aid Antibiotic Cream comes in a portable, travel-size tube, perfect for on-the-go use. Keep it in your first aid cabinet, travel bag, car, or camping gear. Its compact size makes it ideal for quick first aid therapy wherever you are—home, work, or outdoors.
•MAXIMUM STRENGTH PROTECTION: This First Aid antibiotic and pain relief cream is designed to offer maximum strength protection for wounds, burns, and scrapes. It helps clean, protect, and soothe injured skin while providing lasting relief from pain and irritation.
•PHARMACEUTICAL-GRADE QUALITY: Manufactured to the highest pharmaceutical standards, Globe Triple Antibiotic Cream + Pain Relief ensures reliable infection protection. Each tube is formulated for safe use, and is packaged with an NDC code for added confidence in its medical-grade care.

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$12.99

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Neosporin

Neosporin + Lidocaine First Aid Antibiotic Ointment, Maximum Strength & Fast-Acting Topical Pain Reliever, 24-Hour Infection Protection That Numbs Away The Pain, Bacitracin Zinc, 0.5 oz

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•0.5-ounce tube of Neosporin + Lidocaine Pain Relieving Antibiotic Ointment for first aid wound care of minor cuts, scrapes, and burns
•Topical antibiotic ointment provides 24-hour infection protection of minor wounds and helps to reduce pain with maximum-strength, fast-acting lidocaine to numb the area
•Contains bacitracin zinc, neomycin sulfate and polymyxin B sulfate antibiotics to help prevent wound infection of minor cuts, scrapes, and burns and fast-acting lidocaine as an external analgesic for maximum-strength numbing and pain relief
•The antibiotic ointment from the #1 doctor recommended brand not only helps fight infection for 24 hours, but also numbs away the pain, making it a great addition to your first-aid kit and wound care supplies
•For best results, clean the affected area, apply a small amount of the topical antibiotic and pain relief numbing ointment 1 to 3 times daily, and cover with a sterile bandage

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$8.28

$11.11

-25%

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CareAll

CareAll Triple Antibiotic Ointment + Pain Relief 1.0 oz (2 Pack), Dual Action First Aid for Minor Scrapes, Cuts, and Burns to Help Prevent Infection While Providing Maximum Strength Pain Relief.

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•FIRST AID PLUS PAIN RELIEF Triple Antibiotic Ointment for the prevention of infections in minor cuts, scrapes and burns while providing maximum strength pain relief.
•FORMULATED with you in mind. CareALL Triple Antibiotic plus pain relief ingredients are phthalate-free, paraben-free, dye-free, and fragrance-free.
•ACTIVE INGREDIENTS Compare to the Active Ingredients to Leading Brand. Active Ingredients (in each gram): Bacitracin Zinc 500 Units, Neomycin Sulfate 3.5mg, Polymyxin B Sulfate 10,000 units, Pramoxine HCI 10mg
•TAMPER PROOF each 1oz Tube has a tamper evident foil safety seal for your safety.
•FDA REGISTERED with NDC# (National Drug Code Number) printed on packaging with LOT # and Expiration Date. For External Use Only.

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$6.49

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Globe Pharmacy

Globe First Aid Antibiotic Cream with Neomycin, Polymyxin B, Pramoxine, Soothes Painful Cuts, Burns and Scrapes, 24 Hour Infection Protection (1 Tube)

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•FIRST AID ANTIBIOTIC + PAIN RELIEF CREAM: Globe First Aid Antibiotic + Pain Relief Cream in a convenient sealed tube for high powered first aid wound care for minor cuts, scrapes, and burns.
•INGREDIENTS: Globe First Aid Antibiotic + Pain Relief Cream contains the same active antibiotic ingredients as the leading First Aid Antibiotic Plus Pain Relief Name Brand: Neomycin Sulfate, Polymyxin B Sulfate, and Pramoxine precisely formulated in a Ointment base to provide powerful 24-hour Infection Protection and Pain Relief.
•EASY TO TAKE WITH YOU: Keep Globe First Aid Antibiotic + Pain Relief Cream in your medicine closet, car, camping bag, purse, kitchen drawer, kid's backpack, and even your travel carry-on luggage. The convenience of the tube size can go with you anywhere.
•QUALITY: Manufactured in accordance with the highest pharmaceutical manufacturing processes and contains a NDC for 100% confidence. Trifecta Pharmaceuticals USA is located in Fort Lauderdale, Florida. All Globe Health Products are Manufactured at US Audited Facilities.

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$4.43

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Globe

Globe (4 Pack Triple Antibiotic + Pain Relief Ointment 1oz, First Aid Antibiotic, Soothes Pain, Cuts, Burns and Scrapes 24 Hour Infection Protection

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•FIRST AID ANTIBIOTIC + PAIN RELIEF Ointment: Globe Dual-Action Ointment comes in a convenient sealed tube for high powered first aid wound care for minor cuts, scrapes, and burns.
•FIRST AID KIT: Globe Dual-Action Ointment is a must have product for your first aid kit. helps fight infection for 24 hours, but also soothes & reduces pain, making it a great addition to your first-aid kit and wound care supplies.
•INGREDIENTS: Globe Dual-Action Ointment contains the same active antibiotic ingredients as the leading First Aid Antibiotic Plus Pain Relief Name Brand: Neomycin Sulfate, Polymyxin B Sulfate, Bacitracin, and Pramoxine precisely formulated in a Cream base to provide powerful 24-hour Infection Protection and Pain Relief.
•EASY TO TAKE WITH YOU: Keep Globes Dual-Action Ointment in your medicine closet, car, camping bag, purse, kitchen drawer, kid's backpack, and even your travel carry on luggage. The convenience of the tube size can go with you anywhere.
•EASY TO TAKE WITH YOU: Keep Globes Dual-Action Ointment in your medicine closet, car, camping bag, purse, kitchen drawer, kid's backpack, and even your travel carry on luggage. The convenience of the tube size can go with you anywhere.

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$9.88

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Globe Pharmacy

(2 Pack) Globe First Aid Antibiotic Cream + Pain Relief, Neomycin, Polymyxin B, Pramoxine HCl, Soothes Painful Cuts, Burns and Scrapes, 24 Hour Infection Protection

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•FIRST AID ANTIBIOTIC + PAIN RELIEF CREAM: Globe Triple Antibiotic + Pain Relief Cream in a convenient sealed tube for high powered first aid wound care for minor cuts, scrapes, and burns.
•INGREDIENTS: Globe Triple Antibiotic + Pain Relief Cream contains the same active antibiotic ingredients as the leading First Aid Antibiotic Plus Pain Relief Name Brand: Neomycin Sulfate, Polymyxin B Sulfate, and Pramoxine precisely formulated in a Ointment base to provide powerful 24-hour Infection Protection and Pain Relief.
•EASY TO TAKE WITH YOU: Keep Globe Triple Antibiotic + Pain Relief Cream in your medicine closet, car, camping bag, purse, kitchen drawer, kid's backpack, and even your travel carry-on luggage. The convenience of the tube size can go with you anywhere.
•QUALITY: Manufactured in accordance with the highest pharmaceutical manufacturing processes and contains a NDC for 100% confidence. Trifecta Pharmaceuticals USA is a family business based in sunny Fort Lauderdale, Florida USA.

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$8.99

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